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Development of a compact, IoT-enabled electronic nose for breath analysis

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Tiele, Akira, Wicaksono, Alfian, Ayyala, Sai Kiran and Covington, James A. (2020) Development of a compact, IoT-enabled electronic nose for breath analysis. Electronics, 9 (1). 84. doi:10.3390/electronics9010084 ISSN 2079-9292.

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Official URL: http://dx.doi.org/10.3390/electronics9010084

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Abstract

In this paper, we report on an in-house developed electronic nose (E-nose) for use with breath analysis. The unit consists of an array of 10 micro-electro-mechanical systems (MEMS) metal oxide (MOX) gas sensors produced by seven manufacturers. Breath sampling of end-tidal breath is achieved using a heated sample tube, capable of monitoring sampling-related parameters, such as carbon dioxide (CO2), humidity, and temperature. A simple mobile app was developed to receive real-time data from the device, using Wi-Fi communication. The system has been tested using chemical standards and exhaled breath samples from healthy volunteers, before and after taking a peppermint capsule. Results from chemical testing indicate that we can separate chemical standards (acetone, isopropanol and 1-propanol) and different concentrations of isobutylene. The analysis of exhaled breath samples demonstrate that we can distinguish between pre- and post-consumption of peppermint capsules; area under the curve (AUC): 0.81, sensitivity: 0.83 (0.59–0.96), specificity: 0.72 (0.47–0.90), p-value: <0.001. The functionality of the developed device has been demonstrated with the testing of chemical standards and a simplified breath study using peppermint capsules. It is our intention to deploy this system in a UK hospital in an upcoming breath research study.

Item Type: Journal Article
Subjects: Q Science > QC Physics
Q Science > QP Physiology
R Medicine > RA Public aspects of medicine
T Technology > T Technology (General)
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH): Olfactometry -- Computer simulation, Olfactory sensors -- Computer simulation, Breath tests , Respirators (Medical equipment) , Internet of things , Embedded Internet devices
Journal or Publication Title: Electronics
Publisher: MDPI
ISSN: 2079-9292
Official Date: 1 January 2020
Dates:
DateEvent
1 January 2020Published
28 December 2019Accepted
Volume: 9
Number: 1
Article Number: 84
DOI: 10.3390/electronics9010084
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 7 January 2020
Date of first compliant Open Access: 15 January 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDIndonesia.‏ Departemen Keuanganhttp://viaf.org/viaf/148921821

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