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Functional genomic analysis of bacterial lignin degraders : diversity in mechanisms of lignin oxidation and metabolism

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Granja-Travez, Rommel Santiago, Persinoti, Gabriela Felix, Squina, Fabio M. and Bugg, Timothy D. H. (2020) Functional genomic analysis of bacterial lignin degraders : diversity in mechanisms of lignin oxidation and metabolism. Applied Microbiology and Biotechnology, 104 . pp. 3305-3320. doi:10.1007/s00253-019-10318-y

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Official URL: https://doi.org/10.1007/s00253-019-10318-y

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Abstract

Although several bacterial lignin-oxidising enzymes have been discovered in recent years, it is not yet clear whether different lignin-degrading bacteria use similar mechanisms for lignin oxidation and degradation of lignin fragments. Genome sequences of 13 bacterial lignin-oxidising bacteria, including new genome sequences for Microbacterium phyllosphaerae and Agrobacterium sp., were analysed for the presence of lignin-oxidising enzymes and aromatic degradation gene clusters that could be used to metabolise the products of lignin degradation. Ten bacterial genomes contain DyP-type peroxidases, and ten bacterial strains contain putative multi-copper oxidases (MCOs), both known to have activity for lignin oxidation. Only one strain lacks both MCOs and DyP-type peroxidase genes. Eleven bacterial genomes contain aromatic degradation gene clusters, of which ten contain the central β-ketoadipate pathway, with variable numbers and types of degradation clusters for other aromatic substrates. Hence, there appear to be diverse metabolic strategies used for lignin oxidation in bacteria, while the β-ketoadipate pathway appears to be the most common route for aromatic metabolism in lignin-degrading bacteria.

Item Type: Journal Article
Subjects: Q Science > QK Botany
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Lignin, Lignin -- Biodegradation, Gene mapping
Journal or Publication Title: Applied Microbiology and Biotechnology
Publisher: Springer
ISSN: 0175-7598
Official Date: April 2020
Dates:
DateEvent
April 2020Published
22 February 2020Available
11 December 2019Accepted
Volume: 104
Page Range: pp. 3305-3320
DOI: 10.1007/s00253-019-10318-y
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: This is a post-peer-review, pre-copyedit version of an article published in Applied Microbiology and Biotechnology The final authenticated version is available online at: https://doi.org/10.1007/s00253-019-10318-y
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/P01738X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
2015/50590-4Fundação de Amparo à Pesquisa do Estado de São Paulohttp://viaf.org/viaf/147398725
UNSPECIFIEDEcuador. Secretaría de Educación Superior, Ciencia, Tecnología e Innovaciónhttp://viaf.org/viaf/313498219
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