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Functional genomic analysis of bacterial lignin degraders : diversity in mechanisms of lignin oxidation and metabolism
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Granja-Travez, Rommel Santiago, Persinoti, Gabriela Felix, Squina, Fabio M. and Bugg, Timothy D. H. (2020) Functional genomic analysis of bacterial lignin degraders : diversity in mechanisms of lignin oxidation and metabolism. Applied Microbiology and Biotechnology, 104 . pp. 3305-3320. doi:10.1007/s00253-019-10318-y
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WRAP-Functional-genomic-bacterial-lignin-metabolism-Bugg-2020.pdf - Accepted Version - Requires a PDF viewer. Download (2078Kb) | Preview |
Official URL: https://doi.org/10.1007/s00253-019-10318-y
Abstract
Although several bacterial lignin-oxidising enzymes have been discovered in recent years, it is not yet clear whether different lignin-degrading bacteria use similar mechanisms for lignin oxidation and degradation of lignin fragments. Genome sequences of 13 bacterial lignin-oxidising bacteria, including new genome sequences for Microbacterium phyllosphaerae and Agrobacterium sp., were analysed for the presence of lignin-oxidising enzymes and aromatic degradation gene clusters that could be used to metabolise the products of lignin degradation. Ten bacterial genomes contain DyP-type peroxidases, and ten bacterial strains contain putative multi-copper oxidases (MCOs), both known to have activity for lignin oxidation. Only one strain lacks both MCOs and DyP-type peroxidase genes. Eleven bacterial genomes contain aromatic degradation gene clusters, of which ten contain the central β-ketoadipate pathway, with variable numbers and types of degradation clusters for other aromatic substrates. Hence, there appear to be diverse metabolic strategies used for lignin oxidation in bacteria, while the β-ketoadipate pathway appears to be the most common route for aromatic metabolism in lignin-degrading bacteria.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QK Botany | ||||||||||||
| Divisions: | Faculty of Science > Chemistry | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Lignin, Lignin -- Biodegradation, Gene mapping | ||||||||||||
| Journal or Publication Title: | Applied Microbiology and Biotechnology | ||||||||||||
| Publisher: | Springer | ||||||||||||
| ISSN: | 0175-7598 | ||||||||||||
| Official Date: | April 2020 | ||||||||||||
| Dates: |
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| Volume: | 104 | ||||||||||||
| Page Range: | pp. 3305-3320 | ||||||||||||
| DOI: | 10.1007/s00253-019-10318-y | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Publisher Statement: | This is a post-peer-review, pre-copyedit version of an article published in Applied Microbiology and Biotechnology The final authenticated version is available online at: https://doi.org/10.1007/s00253-019-10318-y | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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