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Tissue-engineered trachea consisting of electrospun patterned scPLA/GO‑g‑IL fibrous membranes with antibacterial property and 3D-printed skeletons with elasticity
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Kang, Yuan, Wang, Chaoli, Qiao, Youbei, Gu, Junwei, Zhang, Han, Peijs, Ton, Kong, Jie, Zhang, Guangcheng and Shi, Xuetao (2019) Tissue-engineered trachea consisting of electrospun patterned scPLA/GO‑g‑IL fibrous membranes with antibacterial property and 3D-printed skeletons with elasticity. Biomacromolecules, 20 (4). pp. 1765-1776. doi:10.1021/acs.biomac.9b00160 ISSN 1525-7797.
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Official URL: http://dx.doi.org/10.1021/acs.biomac.9b00160
Abstract
In this study, a tissue-engineered trachea, consisting of multilevel structural electrospun polylactide (PLA) membranes enveloping 3D-printed thermoplastic polyurethane (TPU) skeletons, was developed to create a mechanically robust, antibacterial and bioresorbable graft for the tracheal reconstruction. The study design incorporated two distinct uses of stereocomplex PLA: patterned electrospun fibers to enhance tissue integration compared to the random layered fibers, meanwhile possessing good antibacterial property; and 3D-printed TPU scaffold with elasticity to provide external support and protection. Herein, ionic liquid (IL)-functioned graphene oxide (GO) was synthesized and presented enhanced mechanical and hydrophilicity properties. More interesting, antibacterial activity of the GO-g-IL modified PLA membranes were proved by Escherichia coli and Staphylococcus aureus, showing superior antibacterial effect compared to single GO or IL. The synergistic antibacterial effect could be related to that GO break cytomembrane of bacteria by its extremely sharp edges, while IL works by electrostatic interaction between its cationic structures and electronegative phosphate groups of bacteria membranes, leading to the loss of cell electrolyte and cell death. Hence, after L929 fibroblast cells were seeded on patterned fibrous membranes with phenotypic shape, further effective cell infiltration, cell proliferation and attachment were observed. In addition, the tissue-engineered trachea scaffolds were implanted into rabbit models. The in vivo result confirmed that the scaffolds with patterned membranes manifested favorable biocompatibility and promoted tissue regeneration.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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| Journal or Publication Title: | Biomacromolecules | ||||||||
| Publisher: | American Chemical Society | ||||||||
| ISSN: | 1525-7797 | ||||||||
| Official Date: | 8 April 2019 | ||||||||
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| Volume: | 20 | ||||||||
| Number: | 4 | ||||||||
| Page Range: | pp. 1765-1776 | ||||||||
| DOI: | 10.1021/acs.biomac.9b00160 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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