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A key regulatory protein for flagellum length control in stable flagella

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Atkins, Madison, Týč, Jiří, Shafiq, Shahaan, Ahmed, Manu, Bertiaux, Eloïse, De Castro Neto, Artur Leonel, Sunter, Jack, Bastin, Philippe, Dean, Samuel and Vaughan, Sue (2019) A key regulatory protein for flagellum length control in stable flagella. Working Paper. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory. (Unpublished)

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Official URL: http://dx.doi.org/10.1101/872952

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Abstract

Cilia and flagella are highly conserved microtubule-based organelles that have important roles in cell motility and sensing [1]. They can be highly dynamic and short lived such as primary cilia or Chlamydomonas [2] or very stable and long lived such as those in spermatozoa [3] photoreceptors [4] or the flagella of many protist cells [3,4]. Although there is a wide variation in length between cell types, there is generally a defined length for a given cell type [1]. Many unicellular flagellated and ciliated organisms have an additional challenge as they must maintain flagella/cilia at a defined length whilst also growing new flagella/cilia in the same cell. It is not currently understood how this is achieved.

Item Type: Working or Discussion Paper (Working Paper)
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: BioRxiv
Publisher: Cold Spring Harbor Laboratory
Place of Publication: Cold Spring Harbor, New York
Book Title: A key regulatory protein for flagellum length control in stable flagella
Official Date: 11 December 2019
Dates:
DateEvent
11 December 2019Available
DOI: 10.1101/872952
Institution: University of Warwick
Status: Not Peer Reviewed
Publication Status: Unpublished
Access rights to Published version: Restricted or Subscription Access

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