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Biotinylated photoactive Pt(IV) anticancer complexes

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Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian and Sadler, Peter J. (2020) Biotinylated photoactive Pt(IV) anticancer complexes. Chemical Communications, 56 (15). pp. 2320-2323. doi:10.1039/c9cc07845b ISSN 1359-7345.

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Official URL: https://doi.org/10.1039/c9cc07845b

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Abstract

Novel biotinylated diazido-Pt(IV) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history
Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Antineoplastic agents, Apoptosis, Photochemistry, Diazines, Avidin, Irradiation
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Official Date: 28 January 2020
Dates:
DateEvent
28 January 2020Available
18 December 2019Accepted
Volume: 56
Number: 15
Page Range: pp. 2320-2323
DOI: 10.1039/c9cc07845b
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Copyright Holders: © The Royal Society of Chemistry 2020
Date of first compliant deposit: 16 January 2020
Date of first compliant Open Access: 27 April 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
EP/G006792 [EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/F034210/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
NF160307Royal Societyhttp://dx.doi.org/10.13039/501100000288
209173/Z/17/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
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