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Biotinylated photoactive Pt(IV) anticancer complexes
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Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian and Sadler, Peter J. (2020) Biotinylated photoactive Pt(IV) anticancer complexes. Chemical Communications, 56 (15). pp. 2320-2323. doi:10.1039/c9cc07845b
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Official URL: https://doi.org/10.1039/c9cc07845b
Abstract
Novel biotinylated diazido-Pt(IV) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Chemistry | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Antineoplastic agents, Apoptosis, Photochemistry, Diazines, Avidin, Irradiation | ||||||||||||||||||
| Journal or Publication Title: | Chemical Communications | ||||||||||||||||||
| Publisher: | Royal Society of Chemistry | ||||||||||||||||||
| ISSN: | 1359-7345 | ||||||||||||||||||
| Official Date: | 28 January 2020 | ||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 16 January 2020 | ||||||||||||||||||
| Volume: | 56 | ||||||||||||||||||
| Number: | 15 | ||||||||||||||||||
| Page Range: | pp. 2320-2323 | ||||||||||||||||||
| DOI: | 10.1039/c9cc07845b | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| Copyright Holders: | © The Royal Society of Chemistry 2020 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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