The Library
Biotinylated photoactive Pt(IV) anticancer complexes
Tools
Tools
Tools
Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian and Sadler, Peter J. (2020) Biotinylated photoactive Pt(IV) anticancer complexes. Chemical Communications, 56 (15). pp. 2320-2323. doi:10.1039/c9cc07845b ISSN 1359-7345.
|
PDF
WRAP-Biotinylated-photoactive-anticancer-complexes-Shi-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (1987Kb) | Preview |
|
![[img]](https://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP-Biotinylated-photoactive-anticancer-complexes-Shi-2020.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1491Kb) |
|
|
PDF
WRAP-Supplementary-information-Shi-2020.pdf - Supplemental Material Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1254Kb) |
Official URL: https://doi.org/10.1039/c9cc07845b
Abstract
Novel biotinylated diazido-Pt(IV) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a.
| Item Type: | Journal Article | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history Q Science > QP Physiology R Medicine > RC Internal medicine |
||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Antineoplastic agents, Apoptosis, Photochemistry, Diazines, Avidin, Irradiation | ||||||||||||||||||
| Journal or Publication Title: | Chemical Communications | ||||||||||||||||||
| Publisher: | Royal Society of Chemistry | ||||||||||||||||||
| ISSN: | 1359-7345 | ||||||||||||||||||
| Official Date: | 28 January 2020 | ||||||||||||||||||
| Dates: |
|
||||||||||||||||||
| Volume: | 56 | ||||||||||||||||||
| Number: | 15 | ||||||||||||||||||
| Page Range: | pp. 2320-2323 | ||||||||||||||||||
| DOI: | 10.1039/c9cc07845b | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| Copyright Holders: | © The Royal Society of Chemistry 2020 | ||||||||||||||||||
| Date of first compliant deposit: | 16 January 2020 | ||||||||||||||||||
| Date of first compliant Open Access: | 27 April 2020 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
||||||||||||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
