UNSPECIFIED (2000) Maternal rubella-specific antibody prevalence in Ethiopian infants. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 94 (3). pp. 333-340. ISSN 0035-9203

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Abstract

In countries with a high transmission rate of rubella the optimal age for universal rubella vaccination of infants is critically dependent upon the rate of loss of maternal antibodies. Few studies have investigated the decay characteristics of such antibodies. Mother:infant pairs were recruited at the Ethio-Swedish Children's Hospital, Addis Ababa, in 1994/95. Rubella antibody levels, determined by radial haemolysis, were available for analysis from 1542 Infants aged 0-12 months, with 942 repeat measures, and from 846 mothers. Decay in seropositivity was well described by a delayed exponential function. The proportion seropositive at age 6, 9, or 12 months was 6-13%, 1-4%, or 0-1%, respectively, dependent upon assay cut-off level. Only infant age and mother's antibody level were important predictors of seropositivity. Results suggest that the success of vaccination at age 9 months or above would be little affected by residual maternal antibodies.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine
Journal or Publication Title:	TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Publisher:	ROYAL SOC TROPICAL MEDICINE
ISSN:	0035-9203
Date:	May 2000
Volume:	94
Number:	3
Number of Pages:	8
Page Range:	pp. 333-340
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/13208

Data sourced from Thomson Reuters' Web of Knowledge

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