
The Library
Association between C-reactive protein with all-cause mortality in ELSA-Brasil cohort
Tools
Maluf, Chams B., Barreto, Sandhi M., Giatti Gonçalves, Luana, Ribeiro, Luiz P., Vidigal, Pedro G., Azevedo, Douglas R. M., Griep, Rosane H., Alvim Matos, Sheila M., Ji, Chen, Cappuccio, Francesco P. and Miller, Michelle A. (2020) Association between C-reactive protein with all-cause mortality in ELSA-Brasil cohort. Journal of Epidemiology and Community Health, 74 (5). pp. 421-427. doi:10.1136/jech-2019-213289 ISSN 0143-005X.
|
PDF
WRAP-association-between-C-reactive-protein-all-cause-mortality-ELSA-Brasil-cohort-Cappuccio-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial 4.0. Download (373Kb) | Preview |
|
![]() |
PDF
WRAP-Association-C-reactive-protein-mortality-Brasil-Cappuccio-2020.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (380Kb) |
Official URL: http://doi.org/10.1136/jech-2019-213289
Abstract
Background: High-sensitive C-reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and it may also be a marker of non-vascular mortality. However, most evidence comes from either North American or European cohorts. The present proposal aims to investigate the association of high-sensitive C-reactive protein with the risk of all-cause mortality in a multi-ethnic Brazilian population
Methods: Cohort data from baseline (2008–2010) of 14 792 subjects participating in the Brazilian Longitudinal Study of Adult Health were used. HsCRP was assayed with Immunochemistry. The association of baseline covariates with all-cause mortality was calculated by Cox regression for univariate model and adjusted for different confounders after mean follow-up of 8.0 ± 1.1 years. The final model was adjusted for age, sex, self-rated race/ethnicity, schooling, health behaviours and prevalent chronic disease.
Results: The risk of death increased steadily by quartiles of hsCRP from 1.45 (95% Confidence Interval: 1.05, 2.01) in Quartile 2 to 1.95 (1.42, 2.69) in Quartile 4 compared to Quartile 1. Furthermore, the persistence of a significant graded association after the exclusion of deaths in the first year of follow-up suggests that these results are unlikely to be due to reverse causality. Finally, the hazard ratios were unaffected by the exclusion of participants that had self-reported past medical history for diabetes, cancer and chronic obstructive pulmonary disease.
Conclusions: Our study shows that hsCRP levels is associated with mortality in a highly admixed population, independently of a large set of lifestyle and clinical variables.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||
Journal or Publication Title: | Journal of Epidemiology and Community Health | ||||||||
Publisher: | B M J Group | ||||||||
ISSN: | 0143-005X | ||||||||
Official Date: | 15 April 2020 | ||||||||
Dates: |
|
||||||||
Volume: | 74 | ||||||||
Number: | 5 | ||||||||
Page Range: | pp. 421-427 | ||||||||
DOI: | 10.1136/jech-2019-213289 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Copyright Holders: | BMJ | ||||||||
Date of first compliant deposit: | 24 January 2020 | ||||||||
Date of first compliant Open Access: | 9 March 2020 | ||||||||
Funder: | UUKi Rutherford Fund, Brazilian Ministry of Health, Brazilian Ministry of Science and Technology, Brazilian National Research Council | ||||||||
Grant number: | 01060010.00RS; 01060212.00BA; 01060300.00ES; 01060278.00MG; 010601115.00SP; 01060071.00RJ | ||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
![]() |
View Item |
Downloads
Downloads per month over past year