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The persistence of self-injurious and aggressive behavior in males with Fragile X syndrome over 8 years : a longitudinal study of prevalence and predictive risk markers
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Crawford, Hayley, Karakatsani, Efthalia, Singla, Gursharan and Oliver, Chris (2019) The persistence of self-injurious and aggressive behavior in males with Fragile X syndrome over 8 years : a longitudinal study of prevalence and predictive risk markers. Journal of Autism and Developmental Disorders, 49 (7). pp. 2913-2922. doi:10.1007/s10803-019-04002-3 ISSN 0162-3257.
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Official URL: http://dx.doi.org/10.1007/s10803-019-04002-3
Abstract
Self-injurious and aggressive behaviors are common in fragile X syndrome (FXS). However, little is known about the persistence of these behaviors and associated risk markers. We established the prevalence and persistence of self-injurious and aggressive behaviors over eight years in males with FXS, and associations with risk markers. Results showed 77% and 69% persistence rates for self-injurious and aggressive behavior, respectively. Baseline levels of repetitive behavior predicted persistent self-injurious behavior. Chronological age, impulsivity and overactivity were associated with persistent aggressive behavior but only impulsivity predicted persistence. This is the first study to document the persistence of self-injurious and aggressive behavior in FXS over the medium to long term and to identify behavioral risk markers that might facilitate targeted early intervention.
Item Type: | Journal Article | ||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Fragile X syndrome, Self-injurious behavior, Aggressiveness, Mental health, Impulsive personality, Autism, Operant behavior | ||||||
Journal or Publication Title: | Journal of Autism and Developmental Disorders | ||||||
Publisher: | Springer | ||||||
ISSN: | 0162-3257 | ||||||
Official Date: | 15 July 2019 | ||||||
Dates: |
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Volume: | 49 | ||||||
Number: | 7 | ||||||
Page Range: | pp. 2913-2922 | ||||||
DOI: | 10.1007/s10803-019-04002-3 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 23 January 2020 | ||||||
Date of first compliant Open Access: | 23 January 2020 | ||||||
RIOXX Funder/Project Grant: |
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