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Neuropsychological outcomes at 19 years of age following extremely preterm birth
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O'Reilly, Helen, Johnson, Samantha, Ni, Yanyan, Wolke, Dieter and Marlow, Neil (2020) Neuropsychological outcomes at 19 years of age following extremely preterm birth. Pediatrics, 145 (2). e20192087. doi:10.1542/peds.2019-2087 ISSN 0031-4005.
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Official URL: https://doi.org/10.1542/peds.2019-2087
Abstract
Children born extremely preterm (EP) (<26 weeks' gestation) have lower cognitive scores and an increased rate of cognitive impairment compared with their term-born peers. However, the neuropsychological presentation of these EP individuals in adulthood has not been described. The aim of this study was to examine neuropsychological outcomes in early adulthood after EP birth in the 1995 EPICure cohort and to investigate if the rate of intellectual impairment changed longitudinally. A total of 127 young adults born EP and 64 term-born controls had a neuropsychological assessment at 19 years of age examining general cognitive abilities (IQ), visuomotor abilities, prospective memory, and aspects of executive functions and language. Adults born EP scored significantly lower than term-born controls across all neuropsychological tests with effect sizes (Cohen's ) of 0.7 to 1.2. Sixty percent of adults born EP had impairment in at least 1 neuropsychological domain; deficits in general cognitive functioning and visuomotor abilities were most frequent. The proportion of EP participants with an intellectual impairment (IQ <70) increased by 6.7% between 11 and 19 years of age ( = .02). Visuospatial functioning in childhood predicted visuomotor functioning at 19 years. Adults born EP continue to perform lower than their term-born peers in general cognitive abilities as well as across a range of neuropsychological functions, indicating that these young adults do not show improvement overtime. The prevalence of intellectual impairment increased from 11 years into adulthood. [Abstract copyright: Copyright © 2020 by the American Academy of Pediatrics.]
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Pediatrics | ||||||||
Publisher: | American Academy of Pediatrics | ||||||||
ISSN: | 0031-4005 | ||||||||
Official Date: | 1 February 2020 | ||||||||
Dates: |
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Volume: | 145 | ||||||||
Number: | 2 | ||||||||
Article Number: | e20192087 | ||||||||
DOI: | 10.1542/peds.2019-2087 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Copyright Holders: | Copyright © 2020 by the American Academy of Pediatrics | ||||||||
Date of first compliant deposit: | 18 June 2020 |
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