UNSPECIFIED (2000) Endoplasmic reticulum-associated protein degradation. [Journal Item]

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Abstract

The quality control system in the endoplasmic reticulum of eukaryotic cells ensures that newly synthesized proteins that fail to fold into the correct conformation or unassembled orphan subunits of oligomeric proteins are rapidly eliminated by proteolytic degradation. This entails the export of proteins from the endoplasmic reticulum to the cytosol followed by their destruction by the cytosolic ubiquitin/proteasome pathway. While this mechanism effectively prevents the cellular accumulation of non-functional or unwanted endogenous proteins, it renders the cell vulnerable to certain viruses and toxins that are able to subvert this degradative mechanism for their own advantage.

Item Type:	Journal Item
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Publisher:	ACADEMIC PRESS LTD
ISSN:	1084-9521
Date:	June 2000
Volume:	11
Number:	3
Number of Pages:	6
Page Range:	pp. 159-164
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/13250

Data sourced from Thomson Reuters' Web of Knowledge

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