Endoplasmic reticulum-associated protein degradation
UNSPECIFIED (2000) Endoplasmic reticulum-associated protein degradation. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 11 (3). pp. 159-164. ISSN 1084-9521Full text not available from this repository.
The quality control system in the endoplasmic reticulum of eukaryotic cells ensures that newly synthesized proteins that fail to fold into the correct conformation or unassembled orphan subunits of oligomeric proteins are rapidly eliminated by proteolytic degradation. This entails the export of proteins from the endoplasmic reticulum to the cytosol followed by their destruction by the cytosolic ubiquitin/proteasome pathway. While this mechanism effectively prevents the cellular accumulation of non-functional or unwanted endogenous proteins, it renders the cell vulnerable to certain viruses and toxins that are able to subvert this degradative mechanism for their own advantage.
|Item Type:||Journal Item|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Journal or Publication Title:||SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY|
|Publisher:||ACADEMIC PRESS LTD|
|Official Date:||June 2000|
|Number of Pages:||6|
|Page Range:||pp. 159-164|
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