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Targeting of proteins to the twin-arginine transport pathway
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Palmer, Tracy and Stansfeld, Phillip J. (2020) Targeting of proteins to the twin-arginine transport pathway. Molecular Microbiology, 113 (5). pp. 861-871. doi:10.1111/mmi.14461
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Official URL: https://doi.org/10.1111/mmi.14461
Abstract
The twin-arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N-terminal signal sequence containing a highly conserved twin-arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation. [Abstract copyright: © 2020 John Wiley & Sons Ltd.]
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Proteins -- Physiological transport, Proteins -- Secretion, Protein binding | |||||||||
| Journal or Publication Title: | Molecular Microbiology | |||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | |||||||||
| ISSN: | 0950-382X | |||||||||
| Official Date: | May 2020 | |||||||||
| Dates: |
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| Volume: | 113 | |||||||||
| Number: | 5 | |||||||||
| Page Range: | pp. 861-871 | |||||||||
| DOI: | 10.1111/mmi.14461 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Reuse Statement (publisher, data, author rights): | "This is the peer reviewed version of the following article: Palmer, T. and Stansfeld, P.J. (2020), Targeting of proteins to the twin‐arginine transport pathway. Mol Microbiol. Accepted Author Manuscript which has been published in final form at https://doi.org/10.1111/mmi.14461. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| RIOXX Funder/Project Grant: |
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