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Model evaluation of target product profiles of an infant vaccine against respiratory syncytial virus (RSV) in a developed country setting

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Kinyanjui, Timothy, Pan-Ngum, Wirichada, Saralamba, Sompob, Taylor, Sylvia, White, Lisa J. and Nokes, D. James (2020) Model evaluation of target product profiles of an infant vaccine against respiratory syncytial virus (RSV) in a developed country setting. Vaccine: X . 100055. doi:10.1016/j.jvacx.2020.100055 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.jvacx.2020.100055

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Abstract

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in children worldwide and is a significant cause of hospital admissions in young children in England. No RSV vaccine has been licensed but a number are under development. In this work, we present two structurally distinct mathematical models, parameterized using RSV data from the UK, which have been used to explore the effect of introducing an RSV paediatric vaccine to the National programme. We have explored different vaccine properties, and dosing regimens combined with a range of implementation strategies for RSV control. The results suggest that vaccine properties that confer indirect protection have the greatest effect in reducing the burden of disease in children under 5 years. The findings are reinforced by the concurrence of predictions from the two models with very different epidemiological structure. The approach described has general application in evaluating vaccine target product profiles.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Respiratory syncytial virus, Respiratory syncytial virus -- Vaccination, Vaccination of infants, Vaccination of infants -- England
Journal or Publication Title: Vaccine: X
Publisher: Elsevier
ISSN: 2590-1362
Official Date: 31 January 2020
Dates:
DateEvent
31 January 2020Available
29 January 2020Accepted
Article Number: 100055
DOI: 10.1016/j.jvacx.2020.100055
Status: Peer Reviewed
Publication Status: In Press
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
EP/N033701/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
UNSPECIFIEDGlaxoSmithKlinehttp://dx.doi.org/10.13039/100004330
UNSPECIFIEDAlan Turing Institutehttp://dx.doi.org/10.13039/100012338

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