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Model evaluation of target product profiles of an infant vaccine against respiratory syncytial virus (RSV) in a developed country setting
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Kinyanjui, Timothy, Pan-Ngum, Wirichada, Saralamba, Sompob, Taylor, Sylvia, White, Lisa J. and Nokes, D. James (2020) Model evaluation of target product profiles of an infant vaccine against respiratory syncytial virus (RSV) in a developed country setting. Vaccine: X . 100055. doi:10.1016/j.jvacx.2020.100055 (In Press)
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WRAP-model-evaluation-target-product-profiles-infant-vaccine-against-rsv-developed-country-setting-Nokes-2020.pdf - Publisher's Proof Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1112Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.jvacx.2020.100055
Abstract
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in children worldwide and is a significant cause of hospital admissions in young children in England. No RSV vaccine has been licensed but a number are under development. In this work, we present two structurally distinct mathematical models, parameterized using RSV data from the UK, which have been used to explore the effect of introducing an RSV paediatric vaccine to the National programme. We have explored different vaccine properties, and dosing regimens combined with a range of implementation strategies for RSV control. The results suggest that vaccine properties that confer indirect protection have the greatest effect in reducing the burden of disease in children under 5 years. The findings are reinforced by the concurrence of predictions from the two models with very different epidemiological structure. The approach described has general application in evaluating vaccine target product profiles.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus, Respiratory syncytial virus -- Vaccination, Vaccination of infants, Vaccination of infants -- England | ||||||||||||
| Journal or Publication Title: | Vaccine: X | ||||||||||||
| Publisher: | Elsevier | ||||||||||||
| ISSN: | 2590-1362 | ||||||||||||
| Official Date: | 31 January 2020 | ||||||||||||
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| Article Number: | 100055 | ||||||||||||
| DOI: | 10.1016/j.jvacx.2020.100055 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | In Press | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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