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Controlled radical polymerization in dispersed systems for biological applications
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Gurnani, Pratik and Perrier, Sébastien (2020) Controlled radical polymerization in dispersed systems for biological applications. Progress in Polymer Science, 102 . 101209. doi:10.1016/j.progpolymsci.2020.101209 ISSN 00796700.
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WRAP-controlled-radical-polymerization-dispersed-systems-biological-applications-Perrier-2020.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (11Mb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.progpolymsci.2020.1012...
Abstract
Polymeric nanoparticles show great promise in a range of biomedical applications, improving pharmacokinetic properties, dose requirements and immune response in drug delivery and bioimaging. Common synthesis techniques such as self-assembly, while prevalent, are unscalable and require the use of organic solvents, or extensive purification. In contrast, recent developments in dispersed state reversible deactivation radical polymerization allow the preparation of well-defined nanomaterials in fully aqueous environments often achieving full monomer conversion, and thus direct use in biological environments without purification in high quantities. These techniques have allowed the preparation of a variety of nanoparticle architectures (nanogel, latex, micelle, nanoworms, vesicles), using ATRP, RAFT and NMP, which in many cases perform significantly better than free radical alternatives. This review focuses on the biological relevance of RDRP in dispersed systems, covering miniemulsion, dispersion, suspension and emulsion polymerizations.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QD Chemistry T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Polymerization, Emulsion polymerization , Nanostructured materials | ||||||||||||
| Journal or Publication Title: | Progress in Polymer Science | ||||||||||||
| Publisher: | Elsevier | ||||||||||||
| ISSN: | 00796700 | ||||||||||||
| Official Date: | March 2020 | ||||||||||||
| Dates: |
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| Volume: | 102 | ||||||||||||
| Article Number: | 101209 | ||||||||||||
| DOI: | 10.1016/j.progpolymsci.2020.101209 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Reuse Statement (publisher, data, author rights): | © 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| Date of first compliant deposit: | 25 February 2020 | ||||||||||||
| Date of first compliant Open Access: | 13 July 2021 | ||||||||||||
| RIOXX Funder/Project Grant: |
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