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Cell-based therapies for stroke : promising solution or dead end?
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Boltze, Johannes, Abe, Koji, Clarkson, Andrew N., Detante, Olivier, Pimentel-Coelho, Pedro M., Rosado-de-Castro, Paulo H. and Janowski, Miroslaw (2020) Cell-based therapies for stroke : promising solution or dead end? Frontiers in Neurology, 11 . 171. doi:10.3389/fneur.2020.00171 ISSN 1664-2295.
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Official URL: https://doi.org/10.3389/fneur.2020.00171
Abstract
The introduction of recanalization procedures has revolutionized acute stroke management, although the narrow time window, strict eligibility criteria and logistical limitations still exclude the majority of patients from treatment. In addition, residual deficits are present in many patients who undergo therapy, preventing their return to premorbid status. Hence, there is a strong need for novel, and ideally complementary, approaches to stroke management.
In preclinical experiments, cell-based treatments have demonstrated beneficial effects in the subacute and chronic stages following stroke [1; 2; 3] and therefore are considered a promising option to supplement current clinical practice. At the same time, great progress has been made in developing clinically feasible delivery and monitoring protocols [4]. However, efficacy results initially reported in clinical studies fell short of expectations [5] raising concerns that cell treatment might eventually share the ‘dead end fate’ of many previous experimental stroke therapies. This Research Topic reviews some of the latest and most innovative studies to summarize the state of the art in translational cell treatments for stroke.
| Item Type: | Journal Article | ||||||||
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| Alternative Title: | |||||||||
| Subjects: | Q Science > QH Natural history R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Stem cells , Mesenchymal stem cells , Cerebrovascular disease , Cerebrovascular disease -- Treatment | ||||||||
| Journal or Publication Title: | Frontiers in Neurology | ||||||||
| Publisher: | Frontiers Research Foundation | ||||||||
| ISSN: | 1664-2295 | ||||||||
| Official Date: | 3 April 2020 | ||||||||
| Dates: |
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| Volume: | 11 | ||||||||
| Article Number: | 171 | ||||||||
| DOI: | 10.3389/fneur.2020.00171 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 6 March 2020 | ||||||||
| Date of first compliant Open Access: | 11 March 2020 | ||||||||
| Related URLs: |
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