UNSPECIFIED (2000) DNA structure control by polycationic species: Polyamine, cobalt ammines, and di-metallo transition metal chelates. In: 7th International Conference on Circular Dichroism (CD 99), AUG 22-25, 1999, MIERKI, POLAND.

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Abstract

Many polycationic species bind to DNA and induce structural changes. The work reported here is the first phase of a program whose long-term aim is to create a class of simple and inexpensive sequence-selective compounds that will enable enhanced DNA structure control for a wide range of applications. Three classes of molecule have been included in this work: the polyamine spermine (charge: 4(+)) and spermidine (charge: 3(+)) (which are known to induce a wide range of DNA conformational changes but whose binding modes are still not well understood); cobalt (III) ammine transition metal complexes as potential polyamine mimics and [Fe(H2O)(6)](3+); and the first member of a new class of di-metallo tris-chelated cylinders of helical structure (charge 4(+)). Temperature-dependent absorption, circular dichroism, linear dichroism, gel electrophoresis, and molecular modeling data are presented. The cobalt ammines prove to be effective polyamine mimics, although their binding appears to be restricted to backbone and major groove. All the ligands stabilize the DNA, but the 4(+) di-iron tris-chelate does so comparatively weakly and seems to have a preference for single-stranded DNA. All the molecules studied bend the DNA, with the di-iron tris-chelate having a particularly dramatic effect even at very low drug load. (C) 2000 Wiley-Liss, Inc.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Journal or Publication Title:	CHIRALITY
Publisher:	WILEY-LISS
ISSN:	0899-0042
Date:	2000
Volume:	12
Number:	4
Number of Pages:	16
Page Range:	pp. 221-236
Publication Status:	Published
Title of Event:	7th International Conference on Circular Dichroism (CD 99)
Location of Event:	MIERKI, POLAND
Date(s) of Event:	AUG 22-25, 1999
URI:	http://wrap.warwick.ac.uk/id/eprint/13427

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