The Library
The detection of wound infection by ion mobility chemical analysis
Tools
Tools
Tools
Daulton, Emma, Wicaksono, Alfian, Bechar, Janak, Covington, James A. and Hardwicke, Joseph (2020) The detection of wound infection by ion mobility chemical analysis. Biosensors, 10 (3). 19. doi:10.3390/bios10030019 ISSN 2079-6374.
|
PDF
WRAP-detection-wound-infection-ion-mobility-chemical-analysis-Daulton-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (468Kb) | Preview |
Official URL: http://dx.doi.org/10.3390/bios10030019
Abstract
Surgical site infection represents a large burden of care in the National Health Service. Current methods for diagnosis include a subjective clinical assessment and wound swab culture that may take several days to return a result. Both techniques are potentially unreliable and result in delays in using targeted antibiotics. Volatile organic compounds (VOCs) are produced by micro-organisms such as those present in an infected wound. This study describes the use of a device to differentiate VOCs produced by an infected wound vs. colonised wound. Malodourous wound dressings were collected from patients, these were a mix of post-operative wounds and vascular leg ulcers. Wound microbiology swabs were taken and antibiotics commenced as clinically appropriate. A control group of soiled, but not malodorous wound dressings were collected from patients who had a split skin graft (SSG) donor site. The analyser used was a G.A.S. GC-IMS. The results from the samples had a sensitivity of 100% and a specificity of 88%, with a positive predictive value of 90%. An area under the curve (AUC) of 91% demonstrates an excellent ability to discriminate those with an infected wound from those without. VOC detection using GC-IMS has the potential to serve as a diagnostic tool for the differentiation of infected and non-infected wounds and facilitate the treatment of wound infections that is cost effective, non-invasive, acceptable to patients, portable, and reliable.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology T Technology > TD Environmental technology. Sanitary engineering |
||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||
| Library of Congress Subject Headings (LCSH): | Wounds and injuries , Infection -- Prevention, Volatile organic compounds, Gas chromatography, Mass spectrometers , Ion mobility spectroscopy | ||||||
| Journal or Publication Title: | Biosensors | ||||||
| Publisher: | M D P I AG | ||||||
| ISSN: | 2079-6374 | ||||||
| Official Date: | 29 February 2020 | ||||||
| Dates: |
|
||||||
| Volume: | 10 | ||||||
| Number: | 3 | ||||||
| Article Number: | 19 | ||||||
| DOI: | 10.3390/bios10030019 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 11 March 2020 | ||||||
| Date of first compliant Open Access: | 18 March 2020 | ||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
