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Early detection and follow‐up of colorectal neoplasia based on faecal volatile organic compounds

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Bosch, S., Bot, R., Wicaksono, Alfian, Savelkoul, E., Hulst, R., Kuijvenhoven, J., Stokkers, P., Daulton, Emma, Covington, James A., Meij, T. G. J. and Boer, N. K. H. (2020) Early detection and follow‐up of colorectal neoplasia based on faecal volatile organic compounds. Colorectal Disease, 22 (9). pp. 1119-1129. doi:10.1111/codi.15009 ISSN 1462-8910.

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Official URL: http://dx.doi.org/10.1111/codi.15009

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Abstract

Aim:
Early detection and removal of colorectal cancer (CRC) and advanced adenomas (AAs) decreases the incidence of and mortality from the disease. We aimed to evaluate the potential of faecal volatile organic compounds (VOCs) for detection and follow‐up of colorectal adenoma using advanced electronic nose technology.

Method:
This was a prospective multi‐centre case–control cohort including two district hospitals and one tertiary referral hospital. Patients undergoing colonoscopy were instructed to collect a faecal sample prior to bowel cleansing and were included in the study when CRC, AAs, large adenomas (LAs; 0.5–1.0 cm), small adenomas (SAs; 0.1–0.5 cm) or no endoscopic abnormalities (controls) were observed. Patients undergoing polypectomy and controls were asked for a second sample after 3 months. Faecal VOCs were measured with gas chromatography–ion mobility spectrometry. Random forest, support vector machine, Gaussian process and neural net classification were used to evaluate accuracy.

Results:
In total, 14 patients with CRC, 64 with AAs, 69 with LAs, 127 with SAs and 227 controls were included. A second sample was collected from 32 polypectomy patients and 32 controls. Faecal VOCs discriminated CRC and adenomas from control [AUC (95% CI): CRC vs control 0.96 (0.89–1); AA vs control 0.96 (0.93–1); LA vs control 0.96 (0.92–0.99); SA vs control 0.96 (0.94–0.99)]. There were no significant differences between CRC and adenoma groups. Patients with adenomas and controls were discriminated prior to polypectomy, whereas 3 months after polypectomy VOC profiles were similar [T0 adenoma vs control 0.98 (0.95–1); T1 adenoma vs control 0.55 (0.40–0.69)].

Conclusions:
Faecal VOC profiles may be useful for early detection of CRC and adenomas and the timing of polyp surveillance as polypectomy led to a normalization of the VOC profile.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
T Technology > TD Environmental technology. Sanitary engineering
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH): Volatile organic compounds, Olfactory sensors, Colon (Anatomy) -- Cancer, Rectum -- Cancer, Adenoma , Medical screening
Journal or Publication Title: Colorectal Disease
Publisher: Wiley-Blackwell Publishing, Inc.
ISSN: 1462-8910
Official Date: September 2020
Dates:
DateEvent
September 2020Published
10 February 2020Available
3 February 2020Accepted
Volume: 22
Number: 9
Page Range: pp. 1119-1129
DOI: 10.1111/codi.15009
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 11 March 2020
Date of first compliant Open Access: 10 February 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDTakeda Science Foundationhttp://dx.doi.org/10.13039/100007449
UNSPECIFIED Dr. C. J. Vaillant Fondshttps://www.lvc-online.nl/dr-c-j-vaillantfonds

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