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Preclinical detection of non-catheter related late-onset sepsis in preterm infants by fecal volatile compounds analysis : a prospective, multi-center cohort study
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Berkhout, Daniel J. C., Niemarkt, Hendrik J., Andriessen, Peter, Vijlbrief, Daniel C., Bomers, Marije K., Cossey, Veerle, Hulzebos, Christian V., van Kaam, Anton H., Kramer, Boris W., van Lingen, Richard A., Wicaksono, Alfian, Covington, James A., van Weissenbruch, Mirjam M., Benninga, Marc A., de Boer, Nanne K. H. and de Meij, Tim G. J. (2020) Preclinical detection of non-catheter related late-onset sepsis in preterm infants by fecal volatile compounds analysis : a prospective, multi-center cohort study. The Pediatric Infectious Disease Journal, 39 (4). pp. 330-335. doi:10.1097/INF.0000000000002589 ISSN 1532-0987.
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WRAP-preclinical-detection-non-catheter-related-late-onset-sepsis-preterm-infants-fecal-volatile-compounds-analysis-Covington-2020.pdf - Accepted Version - Requires a PDF viewer. Download (1240Kb) | Preview |
Official URL: http://dx.doi.org/10.1097/INF.0000000000002589
Abstract
Background:
Late onset sepsis (LOS) in preterm infants is preceded by fecal volatile organic compound (VOC) alterations, suggesting an etiological role of gut microbiota in LOS rather than being primarily caused by central venous catheters (CVC). To increase our knowledge about the involvement of the gut microbiota in LOS, we analyzed fecal samples from septic infants without a CVC.
Methods:
In this prospective multicenter study, fecal samples were collected daily from all infants born at ≤30 weeks gestation. Fecal VOC profiles up to 3 days prior to sepsis onset from infants with non-catheter–related LOS were compared with profiles from non-septic controls by means of High-Field Asymmetric Waveform Ion Mobility Spectrometry.
Results:
In total, 104 fecal samples were analyzed. Fecal VOC profiles allowed for discrimination between non-catheter–related LOS cases (n = 24) and matched controls (n = 25). Discriminative accuracy increased after focusing on center of origin (area under the curve, sensitivity, specificity; 0.95, 100%, 83%) and after focusing on LOS cases caused by Staphylococcus epidermidis (0.95, 100%, 78%), the most cultured pathogen (n = 11).
Conclusions:
Fecal VOC profiles of preterm LOS infants without a CVC differed from matched controls underlining the increasing notion that aberrations in gut microbiota composition and activity may play a role in LOS etiology.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RB Pathology R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
Library of Congress Subject Headings (LCSH): | Septicemia, Premature infants, Feces -- Examination | ||||||||
Journal or Publication Title: | The Pediatric Infectious Disease Journal | ||||||||
Publisher: | Lippincott Williams & Wilkins | ||||||||
ISSN: | 1532-0987 | ||||||||
Official Date: | April 2020 | ||||||||
Dates: |
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Volume: | 39 | ||||||||
Number: | 4 | ||||||||
Page Range: | pp. 330-335 | ||||||||
DOI: | 10.1097/INF.0000000000002589 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | This is a non-final version of an article published in final form in Berkhout, Daniel J. C., Niemarkt, Hendrik J., Andriessen, Peter, Vijlbrief, Daniel C., Bomers, Marije K., Cossey, Veerle, Hulzebos, Christian V., van Kaam, Anton H., Kramer, Boris W., van Lingen, Richard A., Wicaksono, Alfian, Covington, James A., van Weissenbruch, Mirjam M., Benninga, Marc A., de Boer, Nanne K. H. and de Meij, Tim G. J. (2020) Preclinical detection of non-catheter related late-onset sepsis in preterm infants by fecal volatile compounds analysis : a prospective, multi-center cohort study. The Pediatric Infectious Disease Journal . doi:10.1097/INF.0000000000002589. | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 12 March 2020 | ||||||||
Date of first compliant Open Access: | 6 February 2021 |
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