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Pulmonary eosinophilia and production of MIP-1 alpha are prominent responses to infection with pneumonia virus of mice

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UNSPECIFIED (2000) Pulmonary eosinophilia and production of MIP-1 alpha are prominent responses to infection with pneumonia virus of mice. CELLULAR IMMUNOLOGY, 200 (2). pp. 98-104. ISSN 0008-8749.

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Abstract

Human eosinophils secrete two distinct ribonucleases that have antiviral activity against pathogens of the family Paramyxoviridae. To examine the role of eosinophils and their ribonucleases in host defense against paramyxovirus pathogens in vivo we have developed a mouse model involving a viral pathogen that naturally targets a rodent host. In this work we describe infection of Balb/c mice with pneumonia virus of mice (PVM, strain J3666), a paramyxovirus pathogen found frequently among rodent populations. We show here that pulmonary eosinophilia is an immediate response to infection with PVM, with bronchoalveolar lavage fluid containing 12-14% eosinophils obtained as early as day 3 postinoculation, Infection is accompanied by the production of macrophage inflammatory protein-1-alpha (MIP-1 alpha), a chemokine that has been associated with the pulmonary eosinophilia observed in response to respiratory syncytial virus infection in humans and with enhanced clear ance of influenza virus in mice. Interestingly, we observed no changes in expression of the chemoattractants eotaxin and RANTES in response to PVM infection, and interleukin-5 remained undetectable throughout. These responses-clinical pathology, viral recovery, pulmonary eosinophilia, and production of MIP-1 alpha-will provide a means for exploring the role of eosinophils, eosinophil secretory ribonucleases, and eosinophil chemoattractants in host defense against PVM and related paramyxovirus pathogens in vivo. (C) 2000 Academic Press.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology > QR180 Immunology
Journal or Publication Title: CELLULAR IMMUNOLOGY
Publisher: ACADEMIC PRESS INC
ISSN: 0008-8749
Official Date: 15 March 2000
Dates:
DateEvent
15 March 2000UNSPECIFIED
Volume: 200
Number: 2
Number of Pages: 7
Page Range: pp. 98-104
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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