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Data for Spread and evolution of respiratory syncytial virus A genotype ON1, coastal Kenya, 2010–2015
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Nokes, D. James and Otieno, James R. (2017) Data for Spread and evolution of respiratory syncytial virus A genotype ON1, coastal Kenya, 2010–2015. [Dataset]
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Official URL: https://doi.org/10.7910/DVN/ZLNI4V
Abstract
In February 2012, the novel respiratory syncytial virus (RSV) group A, genotype ON1, was detected in Kilifi County, coastal Kenya. ON1 is characterized by a 72-nt duplication within the highly variable G gene (encoding the immunogenic attachment surface protein). Cases were diagnosed through surveillance of pneumonia in children at the county hospital. Analysis of epidemiologic, clinical, and sequence data of RSV-A viruses detected over 5 RSV seasons (2010/2011 to 2014/2015) indicated the following: 1) replacement of previously circulating genotype GA2 by ON1, 2) an abrupt expansion in the number of ON1 variants detected in the 2014/2015 epidemic, 3) recent accumulation of amino acid substitutions within the ON1 duplicated sequence, and 4) no clear evidence of altered pathogenicity relative to GA2. The study demonstrates the public health importance of molecular surveillance in defining the spread, clinical effects, and evolution of novel respiratory virus variants.
Item Type: | Dataset | |||||||||||||||
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Subjects: | R Medicine > RC Internal medicine | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||||||||
Type of Data: | Experimental data | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus -- Genetic aspects -- Kilifi District (Kenya), Communicable diseases | |||||||||||||||
Publisher: | University of Warwick, Warwick Medical School | |||||||||||||||
Official Date: | 13 May 2017 | |||||||||||||||
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Status: | Not Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Media of Output (format): | .fasta .do .tab .pdf | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Copyright Holders: | University of Warwick | |||||||||||||||
Description: | Data record consists of 3 plain text files, one Stata file, one PDF and the tabular data. |
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