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Data for Towards symmetry driven and nature inspired UV filter design
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Horbury, Michael D. (2019) Data for Towards symmetry driven and nature inspired UV filter design. [Dataset]
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Official URL: https://doi.org/10.5281/zenodo.3275151
Abstract
In plants, sinapate esters offer crucial protection from the deleterious effects of ultraviolet radiation exposure. These esters are a promising foundation for designing UV filters, particularly for the UVA region (400 – 315 nm), where adequate photoprotection is currently lacking. Whilst sinapate esters are highly photostable due to a cis-trans (and vice versa) photoisomerization, the cis-isomer can display increased genotoxicity; an alarming concern for current cinnamate ester-based human sunscreens. To eliminate this potentiality, here we synthesize a sinapate ester with equivalent cis- and trans-isomers. We investigate its photostability through innovative ultrafast spectroscopy on a skin mimic, thus modelling the as close to true environment of sunscreen formulas. These studies are complemented by assessing endocrine disruption activity and antioxidant potential. We contest, from our results, that symmetrically functionalized sinapate esters may show exceptional promise as nature-inspired UV filters in next generation sunscreen formulations.
Item Type: | Dataset | ||||||||||||||||||
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Subjects: | Q Science > QC Physics Q Science > QK Botany R Medicine > RA Public aspects of medicine T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||
Type of Data: | Experimental data | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Ultraviolet radiation -- Physiological effect, Protective coatings, Environmental health, Solar radiation, Nature -- Design, Botanical chemistry, Plant molecular biology | ||||||||||||||||||
Publisher: | University of Warwick, Department of Chemistry | ||||||||||||||||||
Official Date: | 9 July 2019 | ||||||||||||||||||
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Status: | Not Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Copyright Holders: | University of Warwick | ||||||||||||||||||
Description: | Data record contains 23 data files in .csv format. Each file is named according to the corresponding figure in the published article. |
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