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Reducing respiratory syncytial virus (RSV) hospitalization in a lower-income country by vaccinating mothers-to-be and their households
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Brand, Samuel, Munywoki, Patrick, Walumbe, David, Keeling, Matthew James and Nokes, D. James (2020) Reducing respiratory syncytial virus (RSV) hospitalization in a lower-income country by vaccinating mothers-to-be and their households. eLife, 9 . e47003. doi:10.7554/eLife.47003
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Official URL: http://dx.doi.org/10.7554/eLife.47003
Abstract
Respiratory syncytial virus is the leading cause of lower respiratory tract infection among infants. RSV is a priority for vaccine development. In this study, we investigate the potential effectiveness of a two-vaccine strategy aimed at mothers-to-be, thereby boosting maternally acquired antibodies of infants, and their household cohabitants, further cocooning infants against infection. We use a dynamic RSV transmission model which captures transmission both within households and communities, adapted to the changing demographics and RSV seasonality of a low-income country. Model parameters were inferred from past RSV hospitalisations, and forecasts made over a 10-year horizon. We find that a 50% reduction in RSV hospitalisations is possible if the maternal vaccine effectiveness can achieve 75 days of additional protection for newborns combined with a 75% coverage of their birth household co-inhabitants (∼7.5% population coverage).
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QM Human anatomy R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus, Vaccines, Pregnancy -- Immunological aspects | ||||||
| Journal or Publication Title: | eLife | ||||||
| Publisher: | eLife Sciences Publications Ltd. | ||||||
| ISSN: | 2050-084X | ||||||
| Official Date: | 27 March 2020 | ||||||
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| Volume: | 9 | ||||||
| Article Number: | e47003 | ||||||
| DOI: | 10.7554/eLife.47003 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| RIOXX Funder/Project Grant: |
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