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Bovistol B, bovistol D and strossmayerin : Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri
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Banks, Alice M., Song, Lijiang, Challis, Gregory L., Bailey, Andy M. and Foster, Gary D. (2020) Bovistol B, bovistol D and strossmayerin : Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri. PLoS One, 15 (4). e0229925. doi:10.1371/journal.pone.0229925 ISSN 1932-6203.
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Official URL: https://doi.org/10.1371/journal.pone.0229925
Abstract
Basidiomycete fungi are a rich source of natural products with a diverse array of potentially exploitable bioactivities. Two dimeric sesquiterpenes, bovistol B (1) and D (2), and one monomeric sesquiterpene, strossmayerin (7), were isolated from the culture filtrate of the basidiomycete fungus Coprinopsis strossmayeri. The structures were determined through a combination of MS and 1D/2D NMR spectroscopic techniques. Likely monomeric precursors, identified on the basis of HRMS analysis, allow a plausible biosynthetic pathway to be proposed for the biosynthesis of 1 and 2, involving the dimerisation of the monomer through a hetero-Diels-Alder mechanism. A gene cluster, including a putative sesquiterpene 1-11 cyclase, was identified through phylogenetic and RNA-seq analysis, and is proposed to be responsible for the biosynthesis of 1 and 2.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QK Botany Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||
| Library of Congress Subject Headings (LCSH): | Sesquiterpenes, Metabolites, Basidiomycetes, Fungi, Monomers | |||||||||
| Journal or Publication Title: | PLoS One | |||||||||
| Publisher: | Public Library of Science | |||||||||
| ISSN: | 1932-6203 | |||||||||
| Official Date: | 6 April 2020 | |||||||||
| Dates: |
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| Volume: | 15 | |||||||||
| Number: | 4 | |||||||||
| Article Number: | e0229925 | |||||||||
| DOI: | 10.1371/journal.pone.0229925 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 3 April 2020 | |||||||||
| Date of first compliant Open Access: | 27 April 2020 | |||||||||
| RIOXX Funder/Project Grant: |
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