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Apelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosis
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Yin, Haiyan, Zhang, Hui, Kong, Youhua, Wang, Chunmei, Guo, Yan, Gao, Yang, Yuan, Lili, Yang, Xinxin and Chen, Jing (2020) Apelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosis. Neuroscience Letters, 728 . 134948. doi:10.1016/j.neulet.2020.134948 ISSN 0304-3940.
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WRAP-Apelin-protects-auditory-cisplatin-in-vitro-inhibiting-apoptosis-Chen-2020.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1865Kb) | Preview |
Official URL: https://doi.org/10.1016/j.neulet.2020.134948
Abstract
Apelin, a specific endogenous ligand of the G protein-coupled receptor APJ, suppresses oxidative stress and apoptosis in vitro and in vivo. The current study explored whether Apelin protects against toxicity induced by the anticancer drug cisplatin in vitro, and the possible mechanisms that underlie this protective effect. The results showed that Apelin was expressed in the mouse auditory cell line HEI-OC1 and in cochlear hair cells (HCs) and was significantly downregulated by cisplatin, whereas pre-treatment with exogenous Apelin significantly reduced cisplatin-induced apoptosis, and thus protected HEI-OC1 cells and cochlear HCs from cisplatin-induced injury. Furthermore, Apelin reduced reactive oxygen species (ROS) generation, rescued mitochondrial membrane potential disruption, inhibited JNK signaling and attenuated the expression of pro-apoptotic factors in HEI-OC1 cells and in cochlear explants treated with cisplatin. Our findings suggest that Apelin could be used as an otoprotective agent for the prevention of cisplatin-induced ototoxicity.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||||||
| Library of Congress Subject Headings (LCSH): | G proteins, Oxidative stress, Apoptosis, Cisplatin, Hair cells, Cancer -- Treatment | ||||||||||||
| Journal or Publication Title: | Neuroscience Letters | ||||||||||||
| Publisher: | Elsevier Ireland Ltd | ||||||||||||
| ISSN: | 0304-3940 | ||||||||||||
| Official Date: | 29 May 2020 | ||||||||||||
| Dates: |
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| Volume: | 728 | ||||||||||||
| Article Number: | 134948 | ||||||||||||
| DOI: | 10.1016/j.neulet.2020.134948 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| Date of first compliant deposit: | 14 April 2020 | ||||||||||||
| Date of first compliant Open Access: | 8 April 2021 | ||||||||||||
| RIOXX Funder/Project Grant: |
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