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Beyond the disconnectivity hypothesis of schizophrenia
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Rolls, Edmund T., Cheng, Wei, Gilson, Matthieu, Gong, Weikang, Deco, Gustavo, Lo, Chun-Yi Zac, Yang, Albert C, Tsai, Shih-Jen, Liu, Mu-En, Lin, Ching-Po and Feng, Jianfeng (2020) Beyond the disconnectivity hypothesis of schizophrenia. Cerebral Cortex, 30 (3). pp. 1213-1233. doi:10.1093/cercor/bhz161 ISSN 1460-2199.
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Official URL: https://doi.org/10.1093/cercor/bhz161
Abstract
To go beyond the disconnectivity hypothesis of schizophrenia, directed (effective) connectivity was measured between 94 brain regions, to provide evidence on the source of the changes in schizophrenia and a mechanistic model. Effective connectivity (EC) was measured in 180 participants with schizophrenia and 208 controls. For the significantly different effective connectivities in schizophrenia, on average the forward (stronger) effective connectivities were smaller, whereas the backward connectivities tended to be larger. Further, higher EC in schizophrenia was found from the precuneus and posterior cingulate cortex (PCC) to areas such as the parahippocampal, hippocampal, temporal, fusiform, and occipital cortices. These are backward effective connectivities and were positively correlated with the positive symptoms of schizophrenia. Lower effective connectivities were found from temporal and other regions and were negatively correlated with the symptoms, especially the negative and general symptoms. Further, a signal variance parameter was increased for areas that included the parahippocampal gyrus and hippocampus, consistent with the hypothesis that hippocampal overactivity is involved in schizophrenia. This investigation goes beyond the disconnectivity hypothesis by drawing attention to differences in schizophrenia between backprojections and forward connections, with the backward connections from the precuneus and PCC implicated in memory stronger in schizophrenia.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | Cerebral Cortex | ||||||
Publisher: | Oxford University Press (OUP) | ||||||
ISSN: | 1460-2199 | ||||||
Official Date: | March 2020 | ||||||
Dates: |
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Volume: | 30 | ||||||
Number: | 3 | ||||||
Page Range: | pp. 1213-1233 | ||||||
DOI: | 10.1093/cercor/bhz161 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Reuse Statement (publisher, data, author rights): | ** Article version: VoR ** From Crossref via Jisc Publications Router ** History: epub 05-08-2019; issued 05-08-2019; ppub 14-03-2020. ** Licence for VoR version of this article starting on 05-08-2019: https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model | ||||||
Access rights to Published version: | Free Access (unspecified licence, 'bronze OA') | ||||||
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