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Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
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Jacques, Laura C., Panagiotou, Stavros, Baltazar, Murielle, Senghore, Madikay, Khandaker, Shadia, Xu, Rong, Bricio-Moreno, Laura, Yang, Marie, Dowson, Christopher G., Everett, Dean B., Neill, Daniel R. and Kadioglu, Aras (2020) Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. Nature Communications, 11 (1). 1892 . doi:10.1038/s41467-020-15751-6
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Official URL: http://dx.doi.org/10.1038/s41467-020-15751-6
Abstract
Streptococcus pneumoniae serotype 1 is the predominant cause of invasive pneumococcal disease in sub-Saharan Africa, but the mechanism behind its increased invasiveness is not well understood. Here, we use mouse models of lung infection to identify virulence factors associated with severe bacteraemic pneumonia during serotype-1 (ST217) infection. We use BALB/c mice, which are highly resistant to pneumococcal pneumonia when infected with other serotypes. However, we observe 100% mortality and high levels of bacteraemia within 24 hours when BALB/c mice are intranasally infected with ST217. Serotype 1 produces large quantities of pneumolysin, which is rapidly released due to high levels of bacterial autolysis. This leads to substantial levels of cellular cytotoxicity and breakdown of tight junctions between cells, allowing a route for rapid bacterial dissemination from the respiratory tract into the blood. Thus, our results offer an explanation for the increased invasiveness of serotype 1.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Pneumonia, Pneumococcal, Pneumonia, Pneumococcal -- Africa, Sub-Saharan, Lungs -- Infections , Lungs -- Infections -- Africa, Sub-Saharan | ||||||||||||||||||
| Journal or Publication Title: | Nature Communications | ||||||||||||||||||
| Publisher: | Nature Publishing Group | ||||||||||||||||||
| ISSN: | 2041-1723 | ||||||||||||||||||
| Official Date: | 20 April 2020 | ||||||||||||||||||
| Dates: |
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| Volume: | 11 | ||||||||||||||||||
| Number: | 1 | ||||||||||||||||||
| Article Number: | 1892 | ||||||||||||||||||
| DOI: | 10.1038/s41467-020-15751-6 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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