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Dapagliflozin versus placebo on left ventricular remodeling in patients with diabetes and heart failure : The REFORM trial
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Singh, J. S. S., Mordi, I. R., Vickneson, K., Fathi, A., Donnan, P. T., Mohan, Mohapradeep, Choy, A. M. J., Gandy, S., George, J., Khan, F., Person, E. R., Houston, J. G., Struthers, A. D. and Lang, C. C. (2020) Dapagliflozin versus placebo on left ventricular remodeling in patients with diabetes and heart failure : The REFORM trial. Diabetes Care, 43 (6). pp. 1356-1359. doi:10.2337/dc19-2187 ISSN 0149-5992.
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Official URL: https://doi.org/10.2337/dc19-2187
Abstract
OBJECTIVE To determine the effects of dapagliflozin in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) on left ventricular (LV) remodeling using cardiac MRI.
RESEARCH DESIGN AND METHODS We randomized 56 patients with T2DM and HF with LV systolic dysfunction to dapagliflozin 10 mg daily or placebo for 1 year, on top of usual therapy. The primary end point was difference in LV end-systolic volume (LVESV) using cardiac MRI. Key secondary end points included other measures of LV remodeling and clinical and biochemical parameters.
RESULTS In our cohort, dapagliflozin had no effect on LVESV or any other parameter of LV remodeling. However, it reduced diastolic blood pressure and loop diuretic requirements while increasing hemoglobin, hematocrit, and ketone bodies. There was a trend toward lower weight.
CONCLUSIONS We were unable to determine with certainty whether dapagliflozin in patients with T2DM and HF had any effect on LV remodeling. Whether the benefits of dapagliflozin in HF are due to remodeling or other mechanisms remains unknown.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > R Medicine (General) | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Diabetes Care | ||||||||
Publisher: | American Diabetes Association | ||||||||
ISSN: | 0149-5992 | ||||||||
Official Date: | June 2020 | ||||||||
Dates: |
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Volume: | 43 | ||||||||
Number: | 6 | ||||||||
Page Range: | pp. 1356-1359 | ||||||||
DOI: | 10.2337/dc19-2187 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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