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Asymmetric transfer hydrogenation of o-Hydroxyphenyl ketones : utilizing directing effects that optimize the asymmetric synthesis of challenging alcohols
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Zheng, Ye, Clarkson, Guy J. and Wills, Martin (2020) Asymmetric transfer hydrogenation of o-Hydroxyphenyl ketones : utilizing directing effects that optimize the asymmetric synthesis of challenging alcohols. Organic Letters, 22 (9). pp. 3717-3721. doi:10.1021/acs.orglett.0c01213 ISSN 1523-7052.
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Official URL: https://doi.org/10.1021/acs.orglett.0c01213
Abstract
A systematic range of o-hydroxyphenyl ketones were reduced under asymmetric transfer hydrogenation conditions using the C3-tethered catalyst 2. Two directing effects, i.e., an o-hydroxyphenyl coupled to a bulky aromatic on the opposite side of the ketone substrate, combine in a matched manner to deliver reduction products with very high enantiomeric excess.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QD Chemistry | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Catalysts, Aromatic compounds, Ketones, Hydrogenation, Hydroxyacetophenones, Asymmetric synthesis | |||||||||
Journal or Publication Title: | Organic Letters | |||||||||
Publisher: | American Chemical Society (ACS) | |||||||||
ISSN: | 1523-7052 | |||||||||
Official Date: | 1 May 2020 | |||||||||
Dates: |
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Volume: | 22 | |||||||||
Number: | 9 | |||||||||
Page Range: | pp. 3717-3721 | |||||||||
DOI: | 10.1021/acs.orglett.0c01213 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Copyright Holders: | © 2020 American Chemical Society | |||||||||
Date of first compliant deposit: | 12 May 2020 | |||||||||
Date of first compliant Open Access: | 16 April 2021 | |||||||||
RIOXX Funder/Project Grant: |
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