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Moderators of cognitive outcomes from an exercise programme in people with mild to moderate dementia
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Smith, Toby O., Mistry, Dipesh, Lee, Hopin, Dosanjh, Sukhdeep, Finnegan, Susanne, Fordham, Bethany, Nichols, Vivien P., Sheehan, Bart and Lamb, S. E. (Sallie E.) (2020) Moderators of cognitive outcomes from an exercise programme in people with mild to moderate dementia. Journal of the American Geriatrics Society, 68 (9). pp. 2095-2100. doi:10.1111/jgs.16552 ISSN 0002-8614.
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Official URL: https://doi.org/10.1111/jgs.16552
Abstract
OBJECTIVES: To estimate whether baseline participant variables were able to moderate the effect of an exercise intervention on cognition in patients with mild to moderate dementia.
DESIGN: Subgroup analysis of a multi-centre, pragmatic, randomised controlled trial.
SETTING: Community-based gym/rehabilitation centres
PARTICIPANTS: 494 community-dwelling participants with mild to moderate dementia.
INTERVENTION: Participants were randomised to a moderate- to high-intensity aerobic and strength exercise programme or a usual care control group. Experimental group participants attended twice-weekly gym sessions for 60 to 90 minutes duration for four months. Participants were prescribed home exercises for one additional hour per week during the supervised period, and 150 minutes each week after the supervised period.
MEASUREMENTS: Multi-level regression model analyses were undertaken to identify individual moderators of cognitive function measured through the ADAS-Cog at 12 months.
RESULTS: When tested for a formal interaction effect, only cognitive function assessed by the baseline number cancellation test, demonstrated a statistically significant interaction effect (-2.7 points; 95% confidence interval: -5.14 to -0.21).
CONCLUSIONS: People with worse number cancellation test scores may experience greater progression of cognitive decline in response to a moderate- to high-intensity exercise programme. Further analyses to examine whether these findings can be replicated in planned, sufficiently-powered analyses are indicated.
Item Type: | Journal Article | |||||||||
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Subjects: | R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Dementia -- Treatment, Cognition -- Age factors, Cognition disorders in old age -- Patients -- Rehabilitation, Cognitive therapy, Exercise -- Psychological aspects | |||||||||
Journal or Publication Title: | Journal of the American Geriatrics Society | |||||||||
Publisher: | Wiley-Blackwell Publishing, Inc. | |||||||||
ISSN: | 0002-8614 | |||||||||
Official Date: | September 2020 | |||||||||
Dates: |
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Volume: | 68 | |||||||||
Number: | 9 | |||||||||
Page Range: | pp. 2095-2100 | |||||||||
DOI: | 10.1111/jgs.16552 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Reuse Statement (publisher, data, author rights): | "This is the peer reviewed version of the following article: Smith, T.O., Mistry, D., Lee, H., Dosanji, S., Finnegan, S., Fordham, B., Nichols, V.P., Sheehan, B. and Lamb, S.E. (2020), Moderators of Cognitive Outcomes from an Exercise Program in People with Mild to Moderate Dementia. J Am Geriatr Soc., which has been published in final form at https://doi.org/10.1111/jgs.16552. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Copyright Holders: | © The American Geriatrics Society | |||||||||
Date of first compliant deposit: | 4 May 2020 | |||||||||
Date of first compliant Open Access: | 22 May 2021 | |||||||||
Funder: | National Institute of Health Research Health Technology Assessment Programme | |||||||||
Grant number: | 09/80/04 | |||||||||
RIOXX Funder/Project Grant: |
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