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Sequelae of premature birth in young adults
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Hedderich, Dennis M., Boeckh-Behrens, Tobias, Bäuml, Josef G., Menegaux, Aurore, Daamen, Marcel, Zimmer, Claus, Bartmann, Peter, Scheef, Lukas, Boecker, Henning, Wolke, Dieter, Sorg, Christian and Spiro, Judith E. (2021) Sequelae of premature birth in young adults. Clinical Neuroradiology, 31 . pp. 325-333. doi:10.1007/s00062-020-00901-6 ISSN 1869-1439.
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Official URL: http://dx.doi.org/10.1007/s00062-020-00901-6
Abstract
Background and Purpose
Qualitative studies about the abnormalities appreciated on routine magnetic resonance imaging (MRI) sequences in prematurely born adults are lacking. This article aimed at filling this knowledge gap by (1) qualitatively describing routine imaging findings in prematurely born adults, (2) evaluating measures for routine image interpretation and (3) investigating the impact of perinatal variables related to premature birth.
Methods
In this study two board-certified radiologists assessed T1-weighted and FLAIR-weighted images of 100 prematurely born adults born very preterm (VP <32 weeks) and/or at very low birth weight (VLBW <1500 g) and 106 controls born at full term (FT) (mean age 26.8 ± 0.7 years). The number of white matter lesions (WML) was counted according to localization. Lateral ventricle volume (LVV) was evaluated subjectively and by measurements of Evans’ index (EI) and frontal-occipital-horn ratio (FOHR). Freesurfer-based volumetry served as reference standard. Miscellaneous incidental findings were noted as free text.
Results
The LVV was increased in 24.7% of VP/VLBW individuals and significantly larger than in FT controls. This was best identified by measurement of FOHR (AUC = 0.928). Ventricular enlargement was predicted by low gestational age (odds ratio: 0.71, 95% CI 0.51–0.98) and presence of neonatal intracranial hemorrhage (odds ratio: 0.26, 95% CI 0.07–0.92). The numbers of deep and periventricular WML were increased while subcortical WMLs were not.
Conclusion
Enlargement of the LVV and deep and periventricular WMLs are typical sequelae of premature birth that can be appreciated on routine brain MRI. To increase sensitivity of abnormal LVV detection, measurement of FOHR seems feasible in clinical practice.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RJ Pediatrics | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Prematurely born children, Brain damaged children, Central nervous system -- Diseases -- Diagnosis, Nervous system -- Radiography | ||||||||
| Journal or Publication Title: | Clinical Neuroradiology | ||||||||
| Publisher: | Springer | ||||||||
| ISSN: | 1869-1439 | ||||||||
| Official Date: | June 2021 | ||||||||
| Dates: |
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| Volume: | 31 | ||||||||
| Page Range: | pp. 325-333 | ||||||||
| DOI: | 10.1007/s00062-020-00901-6 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 30 April 2020 | ||||||||
| Date of first compliant Open Access: | 30 April 2020 | ||||||||
| RIOXX Funder/Project Grant: |
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