The Library
Bottlebrush glycopolymers from 2-oxazolines and acrylamides for targeting DC-SIGN and MBL
Tools
Beyer, Valentin, Monaco, Alessandra, Napier, Richard, Yilmaz, Gokhan and Becer, C. Remzi (2020) Bottlebrush glycopolymers from 2-oxazolines and acrylamides for targeting DC-SIGN and MBL. Biomacromolecules, 21 (6). pp. 2298-2308. doi:10.1021/acs.biomac.0c00246 ISSN 1525-7797.
|
PDF
WRAP-bottlebrush-glycopolymers-2-oxazolines-acrylamides-targeting-DC-SIGN-MBL-Becer-2020.pdf - Accepted Version - Requires a PDF viewer. Download (2033Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/acs.biomac.0c00246
Abstract
Lectins are omnipresent carbohydrate binding proteins, which are involved in a multitude of biological processes. Unearthing their binding properties is a powerful tool towards the understanding and modification of their functions in biological applications. In here, we present the synthesis of glycopolymers with a brush architecture via a “grafting from” methodology. The use of a versatile 2-oxazoline inimer was demonstrated to open avenues for a wide range of 2-oxazoline/acrylamide bottle brush polymers utilizing aqueous Cu-mediated reversible deactivation radical polymerization (Cu-RDRP). The polymers in the obtained library were assessed on their thermal properties in aqueous solution and their binding towards the C-type animal lectins dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and mannose-binding lectin (MBL) via surface plasmon resonance spectrometry. The encapsulation properties of a hydrophobic drug-mimicking compound demonstrated the potential use of glyco brush copolymers in biological applications.
Item Type: | Journal Article | ||||||
---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry Q Science > QP Physiology T Technology > TP Chemical technology |
||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
Library of Congress Subject Headings (LCSH): | Ring-opening polymerization, Free radical reactions , Polyacrylamide, Lectins, Thermoresponsive polymers | ||||||
Journal or Publication Title: | Biomacromolecules | ||||||
Publisher: | American Chemical Society | ||||||
ISSN: | 1525-7797 | ||||||
Official Date: | 22 April 2020 | ||||||
Dates: |
|
||||||
Volume: | 21 | ||||||
Number: | 6 | ||||||
Page Range: | pp. 2298-2308 | ||||||
DOI: | 10.1021/acs.biomac.0c00246 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Reuse Statement (publisher, data, author rights): | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.biomac.0c00246 | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Date of first compliant deposit: | 30 April 2020 | ||||||
Date of first compliant Open Access: | 22 April 2021 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year