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Bottlebrush glycopolymers from 2-oxazolines and acrylamides for targeting DC-SIGN and MBL
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Beyer, Valentin, Monaco, Alessandra, Napier, Richard, Yilmaz, Gokhan and Becer, C. Remzi (2020) Bottlebrush glycopolymers from 2-oxazolines and acrylamides for targeting DC-SIGN and MBL. Biomacromolecules, 21 (6). pp. 2298-2308. doi:10.1021/acs.biomac.0c00246
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WRAP-bottlebrush-glycopolymers-2-oxazolines-acrylamides-targeting-DC-SIGN-MBL-Becer-2020.pdf - Accepted Version - Requires a PDF viewer. Download (2033Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/acs.biomac.0c00246
Abstract
Lectins are omnipresent carbohydrate binding proteins, which are involved in a multitude of biological processes. Unearthing their binding properties is a powerful tool towards the understanding and modification of their functions in biological applications. In here, we present the synthesis of glycopolymers with a brush architecture via a “grafting from” methodology. The use of a versatile 2-oxazoline inimer was demonstrated to open avenues for a wide range of 2-oxazoline/acrylamide bottle brush polymers utilizing aqueous Cu-mediated reversible deactivation radical polymerization (Cu-RDRP). The polymers in the obtained library were assessed on their thermal properties in aqueous solution and their binding towards the C-type animal lectins dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and mannose-binding lectin (MBL) via surface plasmon resonance spectrometry. The encapsulation properties of a hydrophobic drug-mimicking compound demonstrated the potential use of glyco brush copolymers in biological applications.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science > Chemistry | ||||||
| Library of Congress Subject Headings (LCSH): | Ring-opening polymerization, Free radical reactions , Polyacrylamide, Lectins, Thermoresponsive polymers | ||||||
| Journal or Publication Title: | Biomacromolecules | ||||||
| Publisher: | American Chemical Society | ||||||
| ISSN: | 1525-7797 | ||||||
| Official Date: | 22 April 2020 | ||||||
| Dates: |
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| Volume: | 21 | ||||||
| Number: | 6 | ||||||
| Page Range: | pp. 2298-2308 | ||||||
| DOI: | 10.1021/acs.biomac.0c00246 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Publisher Statement: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.biomac.0c00246 | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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