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Bottlebrush glycopolymers from 2-oxazolines and acrylamides for targeting DC-SIGN and MBL

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Beyer, Valentin, Monaco, Alessandra, Napier, Richard, Yilmaz, Gokhan and Becer, C. Remzi (2020) Bottlebrush glycopolymers from 2-oxazolines and acrylamides for targeting DC-SIGN and MBL. Biomacromolecules, 21 (6). pp. 2298-2308. doi:10.1021/acs.biomac.0c00246

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Official URL: http://dx.doi.org/10.1021/acs.biomac.0c00246

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Abstract

Lectins are omnipresent carbohydrate binding proteins, which are involved in a multitude of biological processes. Unearthing their binding properties is a powerful tool towards the understanding and modification of their functions in biological applications. In here, we present the synthesis of glycopolymers with a brush architecture via a “grafting from” methodology. The use of a versatile 2-oxazoline inimer was demonstrated to open avenues for a wide range of 2-oxazoline/acrylamide bottle brush polymers utilizing aqueous Cu-mediated reversible deactivation radical polymerization (Cu-RDRP). The polymers in the obtained library were assessed on their thermal properties in aqueous solution and their binding towards the C-type animal lectins dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and mannose-binding lectin (MBL) via surface plasmon resonance spectrometry. The encapsulation properties of a hydrophobic drug-mimicking compound demonstrated the potential use of glyco brush copolymers in biological applications.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
T Technology > TP Chemical technology
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Ring-opening polymerization, Free radical reactions , Polyacrylamide, Lectins, Thermoresponsive polymers
Journal or Publication Title: Biomacromolecules
Publisher: American Chemical Society
ISSN: 1525-7797
Official Date: 22 April 2020
Dates:
DateEvent
22 April 2020Published
22 April 2020Accepted
Date of first compliant deposit: 30 April 2020
Volume: 21
Number: 6
Page Range: pp. 2298-2308
DOI: 10.1021/acs.biomac.0c00246
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.biomac.0c00246
Access rights to Published version: Restricted or Subscription Access

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