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Quality and validity of large animal experiments in stroke : a systematic review

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Kringe, L., Sena, E. S., Motschall, E., Bahor, Z., Wang, Q., Herrmann, A. M., Mülling, C., Meckel, S. and Boltze, Johannes (2020) Quality and validity of large animal experiments in stroke : a systematic review. Journal of Cerebral Blood Flow & Metabolism, 40 (11). pp. 2152-2164. doi:10.1177/0271678X20931062

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Official URL: https://doi.org/10.1177/0271678X20931062

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Abstract

An important factor for successful translational stroke research is study quality. Low-quality studies are at risk of biased results and effect overestimation, as has been intensely discussed for small animal stroke research. However, little is known about the methodological rigor and quality in large animal stroke models, which are becoming more frequently used in the field. Based on research in two databases, this systematic review surveys and analyses the methodological quality in large animal stroke research. Quality analysis was based on the Stroke Therapy Academic Industry Roundtable and the Animals in Research: Reporting In Vivo Experiments guidelines. Our analysis revealed that large animal models are utilized with similar shortcomings as small animal models. Moreover, translational benefits of large animal models may be limited due to lacking implementation of important quality criteria such as randomization, allocation concealment, and blinded assessment of outcome. On the other hand, an increase of study quality over time and a positive correlation between study quality and journal impact factor were identified. Based on the obtained findings, we derive recommendations for optimal study planning, conducting, and data analysis/reporting when using large animal stroke models to fully benefit from the translational advantages offered by these models.

Item Type: Journal Article
Alternative Title:
Subjects: Q Science > QL Zoology
R Medicine > RC Internal medicine
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Cerebrovascular disease , Human-animal relationships, Cerebrovascular disease -- Animal models, Laboratory animals
Journal or Publication Title: Journal of Cerebral Blood Flow & Metabolism
Publisher: Sage Publications Ltd
ISSN: 0271-678X
Official Date: 21 November 2020
Dates:
DateEvent
21 November 2020Published
23 June 2020Available
24 April 2020Accepted
Volume: 40
Number: 11
Page Range: pp. 2152-2164
DOI: 10.1177/0271678X20931062
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: Posted ahead of print. Kringe, L., Sena, E. S., Motschall, E., Bahor, Z., Wang, Q., Herrmann, A. M., Mülling, C., Meckel, S. and Boltze, Johannes (2020) Quality and validity of large animal experiments in stroke : a systematic review. Journal of Cerebral Blood Flow & Metabolism. 40(11) 2152-2164. Copyright © 2020 The Author. Reprinted by permission of SAGE Publications. https://doi.org/10.1177/0271678X20931062
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
SA L-SNC 18\1003Stroke Associationhttp://dx.doi.org/10.13039/501100000364
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