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Quality and validity of large animal experiments in stroke : a systematic review
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Kringe, L., Sena, E. S., Motschall, E., Bahor, Z., Wang, Q., Herrmann, A. M., Mülling, C., Meckel, S. and Boltze, Johannes (2020) Quality and validity of large animal experiments in stroke : a systematic review. Journal of Cerebral Blood Flow & Metabolism, 40 (11). pp. 2152-2164. doi:10.1177/0271678X20931062
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Official URL: https://doi.org/10.1177/0271678X20931062
Abstract
An important factor for successful translational stroke research is study quality. Low-quality studies are at risk of biased results and effect overestimation, as has been intensely discussed for small animal stroke research. However, little is known about the methodological rigor and quality in large animal stroke models, which are becoming more frequently used in the field. Based on research in two databases, this systematic review surveys and analyses the methodological quality in large animal stroke research. Quality analysis was based on the Stroke Therapy Academic Industry Roundtable and the Animals in Research: Reporting In Vivo Experiments guidelines. Our analysis revealed that large animal models are utilized with similar shortcomings as small animal models. Moreover, translational benefits of large animal models may be limited due to lacking implementation of important quality criteria such as randomization, allocation concealment, and blinded assessment of outcome. On the other hand, an increase of study quality over time and a positive correlation between study quality and journal impact factor were identified. Based on the obtained findings, we derive recommendations for optimal study planning, conducting, and data analysis/reporting when using large animal stroke models to fully benefit from the translational advantages offered by these models.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QL Zoology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Cerebrovascular disease , Human-animal relationships, Cerebrovascular disease -- Animal models, Laboratory animals | ||||||||
| Journal or Publication Title: | Journal of Cerebral Blood Flow & Metabolism | ||||||||
| Publisher: | Sage Publications Ltd | ||||||||
| ISSN: | 0271-678X | ||||||||
| Official Date: | 21 November 2020 | ||||||||
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| Volume: | 40 | ||||||||
| Number: | 11 | ||||||||
| Page Range: | pp. 2152-2164 | ||||||||
| DOI: | 10.1177/0271678X20931062 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Publisher Statement: | Posted ahead of print. Kringe, L., Sena, E. S., Motschall, E., Bahor, Z., Wang, Q., Herrmann, A. M., Mülling, C., Meckel, S. and Boltze, Johannes (2020) Quality and validity of large animal experiments in stroke : a systematic review. Journal of Cerebral Blood Flow & Metabolism. 40(11) 2152-2164. Copyright © 2020 The Author. Reprinted by permission of SAGE Publications. https://doi.org/10.1177/0271678X20931062 | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| RIOXX Funder/Project Grant: |
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