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Bacterial microevolution and the Pangenome
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Lassalle, Florent and Didelot, Xavier (2020) Bacterial microevolution and the Pangenome. In: Tettelin, H. and Medini, D., (eds.) The Pangenome. Cham: Springer, pp. 129-149. ISBN 9783030382803
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WRAP-Bacterial-microevolution-Pangenome-Didelot-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (692Kb) | Preview |
Official URL: http://doi.org/10.1007/978-3-030-38281-0_6
Abstract
The comparison of multiple genome sequences sampled from a bacterial population reveals considerable diversity in both the core and the accessory parts of the pangenome. This diversity can be analysed in terms of microevolutionary events that took place since the genomes shared a common ancestor, especially deletion, duplication, and recombination. We review the basic modelling ingredients used implicitly or explicitly when performing such a pangenome analysis. In particular, we describe a basic neutral phylogenetic framework of bacterial pangenome microevolution, which is not incompatible with evaluating the role of natural selection. We survey the different ways in which pangenome data is summarised in order to be included in microevolutionary models, as well as the main methodological approaches that have been proposed to reconstruct pangenome microevolutionary history.
Item Type: | Book Item | ||||
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Subjects: | Q Science > QH Natural history Q Science > QR Microbiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Bacterial genetics, Bacterial genomes, Bacteria -- Evolution | ||||
Publisher: | Springer | ||||
Place of Publication: | Cham | ||||
ISBN: | 9783030382803 | ||||
Book Title: | The Pangenome | ||||
Editor: | Tettelin, H. and Medini, D. | ||||
Official Date: | 1 May 2020 | ||||
Dates: |
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Page Range: | pp. 129-149 | ||||
DOI: | 10.1007/978-3-030-38281-0_6 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Copyright Holders: | © The Author(s) 2020 | ||||
Date of first compliant deposit: | 11 May 2020 | ||||
Date of first compliant Open Access: | 11 May 2020 |
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