Action of Myc in vivo - proliferation and apoptosis
UNSPECIFIED (2000) Action of Myc in vivo - proliferation and apoptosis. CURRENT OPINION IN GENETICS & DEVELOPMENT, 10 (1). pp. 100-105. ISSN 0959-437XFull text not available from this repository.
The protein products of many dominant oncogenes are capable of inducing both cell proliferation and apoptosis. Recent experiments employing transgenic mice that express an ectopically regulatable myc gene or protein have begun to elucidate the role of the balance between proliferation and apoptosis in Myc-induced carcinogenesis. An outstanding feature of these experiments is the demonstration that the balance between oncogene-induced proliferation and apoptosis in a given tissue can be a critical determinant in the initiation and maintenance of the tumour.
|Item Type:||Journal Item|
|Subjects:||Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
|Journal or Publication Title:||CURRENT OPINION IN GENETICS & DEVELOPMENT|
|Publisher:||CURRENT BIOLOGY LTD|
|Official Date:||February 2000|
|Number of Pages:||6|
|Page Range:||pp. 100-105|
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