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Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria
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Parker, Hadyn, Tomás, Ruben M. F., Furze, Christopher M., Guy, Collette S. and Fullam, Elizabeth (2020) Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria. Organic & Biomolecular Chemistry (18). pp. 3607-3612. doi:10.1039/D0OB00253D
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Official URL: http://dx.doi.org/10.1039/D0OB00253D
Abstract
The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.
| Item Type: | Journal Article | |||||||||||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science > Chemistry Faculty of Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Mycobacterium tuberculosis , Disaccharides , Disaccharides -- Metabolism, Trehalose , Trehalose -- Synthesis, Mycobacteria | |||||||||||||||||||||||||||
| Journal or Publication Title: | Organic & Biomolecular Chemistry | |||||||||||||||||||||||||||
| Publisher: | Royal Society of Chemistry | |||||||||||||||||||||||||||
| ISSN: | 1477-0520 | |||||||||||||||||||||||||||
| Official Date: | 14 May 2020 | |||||||||||||||||||||||||||
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| Number: | 18 | |||||||||||||||||||||||||||
| Page Range: | pp. 3607-3612 | |||||||||||||||||||||||||||
| DOI: | 10.1039/D0OB00253D | |||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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