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Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

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Parker, Hadyn, Tomás, Ruben M. F., Furze, Christopher M., Guy, Collette S. and Fullam, Elizabeth (2020) Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria. Organic & Biomolecular Chemistry (18). pp. 3607-3612. doi:10.1039/D0OB00253D ISSN 1477-0520.

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Official URL: http://dx.doi.org/10.1039/D0OB00253D

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Abstract

The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QR Microbiology
T Technology > TP Chemical technology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Mycobacterium tuberculosis , Disaccharides , Disaccharides -- Metabolism, Trehalose , Trehalose -- Synthesis, Mycobacteria
Journal or Publication Title: Organic & Biomolecular Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1477-0520
Official Date: 14 May 2020
Dates:
DateEvent
14 May 2020Published
30 April 2020Available
8 April 2020Accepted
Number: 18
Page Range: pp. 3607-3612
DOI: 10.1039/D0OB00253D
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 12 May 2020
Date of first compliant Open Access: 13 May 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
104193/Z/14/Z Wellcome Trusthttp://dx.doi.org/10.13039/100010269
104193/Z/14/BWellcome Trusthttp://dx.doi.org/10.13039/100010269
104193/Z/14/Z Royal Societyhttp://dx.doi.org/10.13039/501100000288
104193/Z/14/BRoyal Societyhttp://dx.doi.org/10.13039/501100000288
RG120405Royal Societyhttp://dx.doi.org/10.13039/501100000288
RP-2019-087Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275
BB/M01116X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
EP/L015307University of Warwickhttp://dx.doi.org/10.13039/501100000741

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