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An analysis of MRI derived cortical complexity in premature-born adults : regional patterns, risk factors, and potential significance
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Hedderich, Dennis M., Bäuml, Josef G., Menegaux, Aurore, Avram, Mihai, Daamen, Marcel, Zimmer, Claus, Bartmann, Peter, Scheef, Lukas, Boecker, Henning, Wolke, Dieter, Gaser, Christian and Sorg, Christian (2020) An analysis of MRI derived cortical complexity in premature-born adults : regional patterns, risk factors, and potential significance. NeuroImage, 208 . 116438. doi:10.1016/j.neuroimage.2019.116438 ISSN 1053-8119.
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WRAP-analysis-MRI-derived-cortical-complexity-premature-born-adults-Wolke-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1223Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.neuroimage.2019.116438
Abstract
Premature birth bears an increased risk for aberrant brain development concerning its structure and function. Cortical complexity (CC) expresses the fractal dimension of the brain surface and changes during neurodevelopment. We hypothesized that CC is altered after premature birth and associated with long-term cognitive development.
One-hundred-and-one very premature-born adults (gestational age <32 weeks and/or birth weight <1500 g) and 111 term-born adults were assessed by structural MRI and cognitive testing at 26 years of age. CC was measured based on MRI by vertex-wise estimation of fractal dimension. Cognitive performance was measured based on Griffiths-Mental-Development-Scale (at 20 months) and Wechsler-Adult-Intelligence-Scales (at 26 years).
In premature-born adults, CC was decreased bilaterally in large lateral temporal and medial parietal clusters. Decreased CC was associated with lower gestational age and birth weight. Furthermore, decreased CC in the medial parietal cortices was linked with reduced full-scale IQ of premature-born adults and mediated the association between cognitive development at 20 months and IQ in adulthood.
Results demonstrate that CC is reduced in very premature-born adults in temporoparietal cortices, mediating the impact of prematurity on impaired cognitive development. These data indicate functionally relevant long-term alterations in the brain’s basic geometry of cortical organization in prematurity.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QC Physics R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Magnetic resonance imaging, Fractals, Premature infants, Brain -- Growth | ||||||||||||||||||
Journal or Publication Title: | NeuroImage | ||||||||||||||||||
Publisher: | Elsevier | ||||||||||||||||||
ISSN: | 1053-8119 | ||||||||||||||||||
Official Date: | March 2020 | ||||||||||||||||||
Dates: |
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Volume: | 208 | ||||||||||||||||||
Article Number: | 116438 | ||||||||||||||||||
DOI: | 10.1016/j.neuroimage.2019.116438 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 14 May 2020 | ||||||||||||||||||
Date of first compliant Open Access: | 15 May 2020 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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