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Regulation of expression of autophagy genes by Atg8a-interacting partners Sequoia, YL-1 and Sir2 in Drosophila
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Jacomin, Anne-Claire, Petridi, Stavroula, Di Monaco, Marisa, Bhujabal, Zambarlal, Jain, Ashish, Mulakkal, Nitha Charles, Palara, Anthimi , Powell, Emma L., Chung, Bonita, Zampronio, Cleidiane, Jones, Alexandra M., Cameron, Alexander, Johansen, Terje and Nezis, Ioannis P. (2020) Regulation of expression of autophagy genes by Atg8a-interacting partners Sequoia, YL-1 and Sir2 in Drosophila. Cell Reports, 31 (8). 107695. doi:10.1016/j.cellrep.2020.107695 ISSN 2211-1247.
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Official URL: https://doi.org/10.1016/j.celrep.2020.107695
Abstract
Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understood. Here, we show that Drosophila Atg8a protein, homologous to mammalian LC3, interacts with the transcription factor Sequoia in a LIR motif-dependent manner. We show that Sequoia depletion induces autophagy in nutrient-rich conditions through the enhanced expression of autophagy genes. We show that Atg8a interacts with YL-1, a component of a nuclear acetyltransferase complex, and that it is acetylated in nutrient-rich conditions. We also show that Atg8a interacts with the deacetylase Sir2, which deacetylates Atg8a during starvation to activate autophagy. Our results suggest a mechanism of regulation of the expression of autophagy genes by Atg8a, which is linked to its acetylation status and its interaction with Sequoia, YL-1, and Sir2.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Cell death, Apoptosis, Homeostasis, Drosophila -- Genetics | ||||||||||||
| Journal or Publication Title: | Cell Reports | ||||||||||||
| Publisher: | Elsevier Inc. | ||||||||||||
| ISSN: | 2211-1247 | ||||||||||||
| Official Date: | 26 May 2020 | ||||||||||||
| Dates: |
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| Volume: | 31 | ||||||||||||
| Number: | 8 | ||||||||||||
| Article Number: | 107695 | ||||||||||||
| DOI: | 10.1016/j.cellrep.2020.107695 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
| Date of first compliant deposit: | 18 May 2020 | ||||||||||||
| Date of first compliant Open Access: | 4 June 2020 | ||||||||||||
| RIOXX Funder/Project Grant: |
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