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Data for 14N1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles
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Grüne, Marvin, Luxenhofer, Robert, Iuga, Dinu, Brown, Steven P. and Pöppler, Ann-Christin (2020) Data for 14N1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles. [Dataset]
Archive (ZIP) (Zip archive)
raw_data_HMQC_PTX_formulations.zip - Published Version Available under License Creative Commons Attribution 4.0. Download (38Mb) |
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Plain Text (Readme file)
read_me_HMQC.docx - Published Version Available under License Creative Commons Attribution 4.0. Download (20Kb) |
Abstract
We present 14N-1H HMQC MAS NMR experiments in the solid state as a promising tool to study amorphous formulations. Poly(2-oxazoline) based polymer micelles loaded with different amounts of the cancer drug paclitaxel serve to highlight the possibilities offered by these experiments: While the very similar 15N chemical shifts hamper a solid-state NMR characterization based on this nucleus, 14N is a very versatile alternative. 14N-1H HMQC experiments yield well-separated signals, which are spread over a large ppm range, provide information on the symmetry of the nitrogen environment and probe 14N-1H through-space proximities.
Item Type: | Dataset | |||||||||||||||||||||
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Subjects: | Q Science > QC Physics R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | |||||||||||||||||||||
Type of Data: | Experimental data | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Magnetic resonance imaging, Paclitaxel, Water-soluble polymers | |||||||||||||||||||||
Publisher: | University of Warwick, Department of Physics | |||||||||||||||||||||
Official Date: | 28 May 2020 | |||||||||||||||||||||
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Status: | Not Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Media of Output (format): | .txt .brml .xye NMR | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Copyright Holders: | University of Warwick | |||||||||||||||||||||
Description: | Data record consists of a zip archive, organised into two subfolders containing NMR and PXRD data, and an explanatory readme file. |
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Date of first compliant deposit: | 28 May 2020 | |||||||||||||||||||||
Date of first compliant Open Access: | 28 May 2020 | |||||||||||||||||||||
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