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Bioelectrical understanding and engineering of cell biology
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Schofield, Zoe, Meloni, Gabriel N., Tran, Peter, Zerfass, Christian, Sena, Giovanni, Hayashi, Yoshikatsu, Grant, Murray R., Contera, Sonia A., Minteer, Shelley D., Kim, Minsu, Prindle, Arthur, Rocha, Paulo, Djamgoz, Mustafa B. A., Pilizota, Teuta, Unwin, Patrick R., Asally, Munehiro and Soyer, Orkun S. (2020) Bioelectrical understanding and engineering of cell biology. Journal of The Royal Society Interface, 17 (166). 20200013. doi:10.1098/rsif.2020.0013 ISSN 1742-5689.
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WRAP-Bioelectrical-understanding-Soyer-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1357Kb) | Preview |
Official URL: http://dx.doi.org/10.1098/rsif.2020.0013
Abstract
The last five decades of molecular and systems biology research have provided unprecedented insights into the molecular and genetic basis of many cellular processes. Despite these insights, however, it is arguable that there is still only limited predictive understanding of cell behaviours. In particular, the basis of heterogeneity in single-cell behaviour and the initiation of many different metabolic, transcriptional or mechanical responses to environmental stimuli remain largely unexplained. To go beyond the status quo, the understanding of cell behaviours emerging from molecular genetics must be complemented with physical and physiological ones, focusing on the intracellular and extracellular conditions within and around cells. Here, we argue that such a combination of genetics, physics and physiology can be grounded on a bioelectrical conceptualization of cells. We motivate the reasoning behind such a proposal and describe examples where a bioelectrical view has been shown to, or can, provide predictive biological understanding. In addition, we discuss how this view opens up novel ways to control cell behaviours by electrical and electrochemical means, setting the stage for the emergence of bioelectrical engineering.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Electrophysiology, Cytology -- Research, Electrochemistry -- Research, Biophysics -- Research | |||||||||
| Journal or Publication Title: | Journal of The Royal Society Interface | |||||||||
| Publisher: | The Royal Society Publishing | |||||||||
| ISSN: | 1742-5689 | |||||||||
| Official Date: | 1 May 2020 | |||||||||
| Dates: |
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| Volume: | 17 | |||||||||
| Number: | 166 | |||||||||
| Article Number: | 20200013 | |||||||||
| DOI: | 10.1098/rsif.2020.0013 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 26 May 2020 | |||||||||
| Date of first compliant Open Access: | 27 May 2020 | |||||||||
| RIOXX Funder/Project Grant: |
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