Recent developments in the area of asymmetric transfer hydrogenation
Wills, Martin, Palmer, Matthew, Smith, Athene, Kenny, Jennifer and Walsgrove, Tim. (2000) Recent developments in the area of asymmetric transfer hydrogenation. Molecules, Volume 5 (Number 1). pp. 4-18. ISSN 1420-3049
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Official URL: http://dx.doi.org/10.3390/50100004
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of alpha-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Hydrogenation, Amino alcohols, Ketones|
|Journal or Publication Title:||Molecules|
|Publisher:||M D P I AG|
|Official Date:||21 January 2000|
|Number of Pages:||15|
|Page Range:||pp. 4-18|
|Access rights to Published version:||Open Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC), SmithKline Beecham, Oxford Asymmetry International plc|
1. Noyori, R. Asymmetric Catalysis in Organic Synthesis; John Wiley and Sons Ltd: NY, 1994.
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