UNSPECIFIED. (2000) Recent developments in the area of asymmetric transfer hydrogenation. MOLECULES, 5 (1). pp. 4-18. ISSN 1420-3049

Abstract

The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of alpha-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.

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