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Recent developments in the area of asymmetric transfer hydrogenation
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Wills, Martin, Palmer, Matthew, Smith, Athene, Kenny, Jennifer and Walsgrove, Tim (2000) Recent developments in the area of asymmetric transfer hydrogenation. Molecules, Volume 5 (Number 1). pp. 4-18. doi:10.3390/50100004
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Official URL: http://dx.doi.org/10.3390/50100004
Abstract
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of alpha-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QD Chemistry | ||||||||
| Divisions: | Faculty of Science > Chemistry | ||||||||
| Library of Congress Subject Headings (LCSH): | Hydrogenation, Amino alcohols, Ketones | ||||||||
| Journal or Publication Title: | Molecules | ||||||||
| Publisher: | M D P I AG | ||||||||
| ISSN: | 1420-3049 | ||||||||
| Official Date: | 21 January 2000 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 28 July 2016 | ||||||||
| Volume: | Volume 5 | ||||||||
| Number: | Number 1 | ||||||||
| Number of Pages: | 15 | ||||||||
| Page Range: | pp. 4-18 | ||||||||
| DOI: | 10.3390/50100004 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), SmithKline Beecham, Oxford Asymmetry International plc |
Data sourced from Thomson Reuters' Web of Knowledge
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