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Recent developments in the area of asymmetric transfer hydrogenation

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UNSPECIFIED (2000) Recent developments in the area of asymmetric transfer hydrogenation. MOLECULES, 5 (1). pp. 4-18. ISSN 1420-3049

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Abstract

The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of alpha-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Journal or Publication Title: MOLECULES
Publisher: MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL
ISSN: 1420-3049
Date: January 2000
Volume: 5
Number: 1
Number of Pages: 15
Page Range: pp. 4-18
Publication Status: Published
URI: http://wrap.warwick.ac.uk/id/eprint/13713

Data sourced from Thomson Reuters' Web of Knowledge

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