Novel streptopyrroles from Streptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities
UNSPECIFIED (2000) Novel streptopyrroles from Streptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities. JOURNAL OF ANTIBIOTICS, 53 (1). pp. 1-11. ISSN 0021-8820Full text not available from this repository.
A series of halogenated pyrrolo [2,1-b] [1,3] benzoxazines (1 similar to 9) was isolated from fermentations of an actinomycete strain X10/78/978 (NCIMB40808), identified as Streptomyces rimosus, during a microbial extract screening programme to identify inhibitors of bacterial histidine kinase. The structures of these compounds were elucidated by spectroscopic methods including the HMQC, HMBC and INADEQUATE NMR experiments. The structure of 1 was confirmed by X-ray crystallographic studies. Compounds 5 and 6 were produced in fermentations in the presence of NaBr and NaI respectively. The most abundant member of the series, streptopyrrole, 1, inhibited the nitrogen regulator II (NRII) histidine kinase from Escherichia roll with an IC50 of 20 mu M and exhibited antimicrobial activity against a range of bacteria and fungi.
|Item Type:||Journal Article|
|Subjects:||T Technology > TP Chemical technology
Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology
R Medicine > RS Pharmacy and materia medica
|Journal or Publication Title:||JOURNAL OF ANTIBIOTICS|
|Publisher:||JAPAN ANTIBIOT RES ASSN|
|Number of Pages:||11|
|Page Range:||pp. 1-11|
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