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14N-1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles
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Grüne, Marvin, Luxenhofer, Robert, Iuga, Dinu, Brown, Steven P. and Pöppler, Ann-Christin (2020) 14N-1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles. Journal of Materials Chemistry B, 8 (31). pp. 6827-6836. doi:10.1039/D0TB00614A ISSN 2050-750X.
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WRAP-14N-1H-HMQC-solid-state-NMR=amorphous-polymer-micelles-Brown-2020.pdf - Accepted Version - Requires a PDF viewer. Download (1162Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/D0TB00614A
Abstract
Amorphous drug-polymer formulations are complex materials and often challenging to characterize, even more so if the small molecule component itself is increasingly complex. In this work, we present 14N-1H HMQC magic-angle spinning (MAS) NMR experiments in the solid state as a promising tool to study amorphous formulations. Poly(2-oxazoline) based polymer micelles loaded with different amounts of the cancer drug paclitaxel serve to highlight the possibilities offered by these experiments: While the dense core of these polymeric micelles prevents an NMR spectroscopic analysis in solution and the very similar 15N chemical shifts hamper a solid-state NMR characterization based on this nucleus, 14N is a very versatile alternative. 14N-1H HMQC experiments yield well-separated signals, which are spread over a large ppm range, provide information on the symmetry of the nitrogen environment and probe 14N-1H through-space proximities. In this way, the overall complexity can be narrowed down to specific N-containing environments. The results from the experiments presented here represent a valuable puzzle piece, which helps to improve the structural understanding of drug-polymer formulations. It can be straightforwardly combined with complementary NMR spectroscopic experiments and other analytical techniques.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QC Physics R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Magnetic resonance imaging, Paclitaxel , Water-soluble polymers | |||||||||||||||||||||
Journal or Publication Title: | Journal of Materials Chemistry B | |||||||||||||||||||||
Publisher: | R S C Publications | |||||||||||||||||||||
ISSN: | 2050-750X | |||||||||||||||||||||
Official Date: | 21 August 2020 | |||||||||||||||||||||
Dates: |
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Volume: | 8 | |||||||||||||||||||||
Number: | 31 | |||||||||||||||||||||
Page Range: | pp. 6827-6836 | |||||||||||||||||||||
DOI: | 10.1039/D0TB00614A | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
Date of first compliant deposit: | 10 June 2020 | |||||||||||||||||||||
Date of first compliant Open Access: | 29 May 2021 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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