Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian and Sadler, Peter J. (2020) Data for Biotinylated photoactive Pt(IV) anticancer complexes. [Dataset]

	Archive (ZIP) (Rar archive) ch-120120-wrap--raw_data.rar - Published Version Available under License Creative Commons Attribution 4.0. Download (2128Kb)
	Plain Text (Readme file) readme (1).txt - Published Version Available under License Creative Commons Attribution 4.0. Download (514b)

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Abstract

Novel biotinylated diazido-Pt(IV) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a.

Item Type:	Dataset
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history Q Science > QP Physiology R Medicine > RC Internal medicine
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Type of Data:	Experimental data
Library of Congress Subject Headings (LCSH):	Antineoplastic agents, Apoptosis, Photochemistry, Diazines, Avidin, Irradiation
Publisher:	University of Warwick, Department of Chemistry
Official Date:	16 January 2020
Dates:	Date Event 16 January 2020 Accepted
Status:	Not Peer Reviewed
Publication Status:	Published
Media of Output (format):	.rar .txt .temp .output .info .par .xml .pdf .emf
Access rights to Published version:	Open Access (Creative Commons)
Copyright Holders:	University of Warwick
Description:	Data record consists of a rar archive, containing the data, and an accompanying readme file. The 1H NMR and 13C NMR spectra and HR-MS spectra of complexes 2a and 2b are listed in the dataset. More information is listed in the ESI and the accompanying readme file.
Date of first compliant deposit:	15 June 2020
Date of first compliant Open Access:	15 June 2020
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID EP/G006792 [EPSRC] Engineering and Physical Sciences Research Council http://dx.doi.org/10.13039/501100000266 EP/F034210/1 [EPSRC] Engineering and Physical Sciences Research Council http://dx.doi.org/10.13039/501100000266 UNSPECIFIED University of Warwick http://dx.doi.org/10.13039/501100000741 NF160307 Royal Society http://dx.doi.org/10.13039/501100000288 209173/Z/17/Z Wellcome Trust http://dx.doi.org/10.13039/100010269
Related URLs:	Related item in WRAP Other
Contributors:	Contribution Name Contributor ID Depositor Shi, Huayun 70747

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