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Changes in quality of life, health status, and other patient-reported outcomes following Simultaneous Pancreas and Kidney Transplantation (SPKT) : a quantitative and qualitative analysis within a UK-wide programme
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Watson, Christopher J. E., Oniscu, Gabriel C., Draper, Heather, Tomson, Charles R. V., Ravanan, Rommel, Johnson, Rachel J., Forsythe, John, Dudley, Chris, Metcalfe, Wendy, Bradley, J. Andrew and Bradley, Clare (2020) Changes in quality of life, health status, and other patient-reported outcomes following Simultaneous Pancreas and Kidney Transplantation (SPKT) : a quantitative and qualitative analysis within a UK-wide programme. Transplant International, 33 (10). pp. 1230-1243. doi:10.1111/tri.13677 ISSN 0934-0874.
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Official URL: https://doi.org/10.1111/tri.13677
Abstract
We examined quality of life (QoL) and other patient‐reported outcome measures (PROMs) in 95 simultaneous pancreas and kidney transplant (SPKT) recipients and 41 patients wait‐listed for SPKT recruited to the UK Access to Transplantation and Transplant Outcome Measures (ATTOM) programme. Wait‐listed patients transplanted within 12 months of recruitment (n = 22) were followed 12 months post‐transplant and compared with those still wait‐listed (n = 19) to examine pre‐ to post‐transplant changes. Qualitative interviews with ten SPKT recipients 12 months post‐transplant were analysed thematically. Cross‐sectional analyses showed several better 12‐month outcomes for SPKT recipients compared with those still wait‐listed, a trend to better health utilities but no difference in diabetes‐specific QoL or diabetes treatment satisfaction. Pre‐ to post‐transplant, SPKT recipients showed improved treatment satisfaction, well‐being, self‐reported health, generic QoL and less negative impact on renal‐specific QoL (ps < 0.05). Health utility values were better overall in transplant recipients and neither these nor diabetes‐specific QoL changed significantly in either group. Pre‐emptive transplant advantages seen in 12‐month cross‐sectional analyses disappeared when controlling for baseline values. Qualitative findings indicated diabetes complications, self‐imposed blood glucose monitoring and dietary restrictions continued to impact QoL negatively post‐transplant. Unrealistic expectations of SPKT caused some disappointment. Measuring condition‐specific PROMs over time will help in demonstrating the benefits and limitations of SPKT.
| Item Type: | Journal Article | ||||||||
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| Subjects: | H Social Sciences > HN Social history and conditions. Social problems. Social reform R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine R Medicine > RD Surgery |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Diabetes -- Patients, Diabetes, Kidneys -- Transplantation, Kidneys -- Transplantation -- Patients , Outcome assessment (Medical care), Quality of life , Pancreas -- Transplantation | ||||||||
| Journal or Publication Title: | Transplant International | ||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
| ISSN: | 0934-0874 | ||||||||
| Official Date: | October 2020 | ||||||||
| Dates: |
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| Volume: | 33 | ||||||||
| Number: | 10 | ||||||||
| Page Range: | pp. 1230-1243 | ||||||||
| DOI: | 10.1111/tri.13677 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 12 June 2020 | ||||||||
| Date of first compliant Open Access: | 26 August 2020 | ||||||||
| RIOXX Funder/Project Grant: |
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