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Hierarchical self-assembled photo-responsive tubisomes from cyclic peptide-bridged amphiphilic block copolymer

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Yang, Jie, Song, Ji‐Inn, Song, Qiao, Rho, Julia Y., Mansfield, Edward D. H., Hall, Stephen C. L., Sambrook, Megan, Huang , Feihe and Perrier, Sébastien (2020) Hierarchical self-assembled photo-responsive tubisomes from cyclic peptide-bridged amphiphilic block copolymer. Angewandte Chemie International Edition, 59 (23). doi:10.1002/anie.201916111 ISSN 1433-7851.

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Official URL: http://dx.doi.org/10.1002/anie.201916111

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Abstract

Typically, the morphologies of the self-assembled nanostructures from block copolymers are limited to spherical micelles, wormlike micelles and vesicles. Herein, we report a new generation of materials with unique shape and structures, cylindrical soft matter particles (tubisomes), obtained from the hierarchical self-assembly of cyclic peptide-bridged amphiphilic diblock copolymers. Additionally, the capacity of obtained photo-responsive tubisomes as potential drug carriers is evaluated. The supramolecular tubisomes described here paves an alternative way for fabricating polymeric tubular structures, and will expand the toolbox for the rational design of functional hierarchical nanostructures.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Nanotubes, Drug delivery systems, Conjugated polymers, Block copolymers
Journal or Publication Title: Angewandte Chemie International Edition
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
ISSN: 1433-7851
Official Date: 2020
Dates:
DateEvent
2020Published
11 February 2020Available
27 January 2020Accepted
Volume: 59
Number: 23
DOI: 10.1002/anie.201916111
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): This is the peer reviewed version of the following article: J. Yang, J.-I. Song, Q. Song, J. Y. Rho, E. D. H. Mansfield, S. C. L. Hall, M. Sambrook, F. Huang, S. Perrier, Angew. Chem. Int. Ed. 2020 , 59 , 8860., which has been published in final form at http://dx.doi.org/10.1002/anie.201916111. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 18 June 2020
Date of first compliant Open Access: 11 February 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
WM130055Royal Societyhttp://dx.doi.org/10.13039/501100000288
TUSUPO647106[ERC] Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
21861130352[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
NAF\R1\180066Royal Societyhttp://dx.doi.org/10.13039/501100000288
TSPBNTMH2020 Marie Skłodowska-Curie Actionshttp://dx.doi.org/10.13039/100010665

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