Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network

Tools
- Tools
+ Tools

Bolborea, Matei, Pollatzek, Eric, Benford, Heather, Sotelo-Hitschfeld, Tamara and Dale, Nicholas (2020) Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network. Proceedings of the National Academy of Sciences of the United States of America, 117 (25). pp. 14473-14481. 201919887. doi:10.1073/pnas.1919887117

[img]
Preview
PDF
WRAP-Hypothalamic-tanycytes-generate-acute-hyperphagia-Bolborea-2020.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1868Kb) | Preview
Official URL: https://doi.org/10.1073/pnas.1919887117

Request Changes to record.

Abstract

Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. To test whether they can activate neurons of the arcuate nucleus, we targeted expression of a Ca2+-permeable channelrhodopsin (CatCh) specifically to tanycytes. Activation of tanycytes ex vivo depolarized orexigenic (neuropeptide Y/agouti-related protein; NPY/AgRP) and anorexigenic (proopiomelanocortin; POMC) neurons via an ATP-dependent mechanism. In vivo, activation of tanycytes triggered acute hyperphagia only in the fed state during the inactive phase of the light–dark cycle.

Item Type: Journal Article
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Hypothalamus, Neuroglia , Food intake, Neural networks (Neurobiology)
Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Publisher: National Academy of Sciences
ISSN: 0027-8424
Official Date: 23 June 2020
Dates:
DateEvent
23 June 2020Published
8 June 2020Available
29 April 2020Accepted
Volume: 117
Number: 25
Page Range: pp. 14473-14481
Article Number: 201919887
DOI: 10.1073/pnas.1919887117
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MR/J003786/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
Related URLs:
  • https://creativecommons.org/licenses/by/...

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us