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Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network
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Bolborea, Matei, Pollatzek, Eric, Benford, Heather, Sotelo-Hitschfeld, Tamara and Dale, Nicholas (2020) Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network. Proceedings of the National Academy of Sciences of the United States of America, 117 (25). pp. 14473-14481. 201919887. doi:10.1073/pnas.1919887117
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WRAP-Hypothalamic-tanycytes-generate-acute-hyperphagia-Bolborea-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1868Kb) | Preview |
Official URL: https://doi.org/10.1073/pnas.1919887117
Abstract
Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. To test whether they can activate neurons of the arcuate nucleus, we targeted expression of a Ca2+-permeable channelrhodopsin (CatCh) specifically to tanycytes. Activation of tanycytes ex vivo depolarized orexigenic (neuropeptide Y/agouti-related protein; NPY/AgRP) and anorexigenic (proopiomelanocortin; POMC) neurons via an ATP-dependent mechanism. In vivo, activation of tanycytes triggered acute hyperphagia only in the fed state during the inactive phase of the light–dark cycle.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QM Human anatomy Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Hypothalamus, Neuroglia , Food intake, Neural networks (Neurobiology) | ||||||||
| Journal or Publication Title: | Proceedings of the National Academy of Sciences of the United States of America | ||||||||
| Publisher: | National Academy of Sciences | ||||||||
| ISSN: | 0027-8424 | ||||||||
| Official Date: | 23 June 2020 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 19 June 2020 | ||||||||
| Volume: | 117 | ||||||||
| Number: | 25 | ||||||||
| Page Range: | pp. 14473-14481 | ||||||||
| Article Number: | 201919887 | ||||||||
| DOI: | 10.1073/pnas.1919887117 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| RIOXX Funder/Project Grant: |
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