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Intravenous bone marrow mononuclear cells transplantation in aged mice increases transcription of glucose transporter 1 and Na+/K+-ATPase at hippocampus followed by restored neurological functions
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Takeuchi, Yukiko, Okinaka, Yuka, Ogawa, Yuko, Kikuchi-Taura, Akie, Kataoka, Yosky, Gul, Sheraz, Claussen, Carsten, Boltze, Johannes and Taguchi, Akihiko (2020) Intravenous bone marrow mononuclear cells transplantation in aged mice increases transcription of glucose transporter 1 and Na+/K+-ATPase at hippocampus followed by restored neurological functions. Frontiers in Aging Neuroscience, 12 . 170. doi:10.3389/fnagi.2020.00170 ISSN 1663-4365.
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WRAP-intavenous-bone-mononuclear-cell-aged-mice-glucose-functions-Boltze-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1825Kb) | Preview |
Official URL: http://dx.doi.org/10.3389/fnagi.2020.00170
Abstract
We recently reported that intravenous bone marrow mononuclear cell (BM-MNC) transplantation in stroke improves neurological function through improvement of cerebral metabolism. Cerebral metabolism is known to diminish with aging, and the reduction of metabolism is one of the presumed causes of neurological decline in the elderly. We report herein that transcription of glucose transporters, monocarboxylate transporters, and Na+/K+-ATPase is downregulated in the hippocampus of aged mice with impaired neurological functions. Intravenous BM-MNC transplantation in aged mice stimulated the transcription of glucose transporter 1 and Na+/K+-ATPase α1 followed by restoration of neurological function. As glucose transporters and Na+/K+-ATPases are closely related to cerebral metabolism and neurological function, our data indicate that BM-MNC transplantation in aged mice has the potential to restore neurological function by activating transcription of glucose transporter and Na+/K+-ATPase. Furthermore, our data indicate that changes in transcription of glucose transporter and Na+/K+-ATPase could be surrogate biomarkers for age-related neurological impairment as well as quantifying the efficacy of therapies.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Hematopoietic stem cells -- Transplantation, Stem cells -- Research, Glucose -- Physiological transport, Adenosine triphosphatase, Cell membranes, Sodium in the body, Potassium in the body | ||||||
| Journal or Publication Title: | Frontiers in Aging Neuroscience | ||||||
| Publisher: | Frontiers Research Foundation | ||||||
| ISSN: | 1663-4365 | ||||||
| Official Date: | 11 June 2020 | ||||||
| Dates: |
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| Volume: | 12 | ||||||
| Article Number: | 170 | ||||||
| DOI: | 10.3389/fnagi.2020.00170 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 19 June 2020 | ||||||
| Date of first compliant Open Access: | 19 June 2020 | ||||||
| RIOXX Funder/Project Grant: |
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