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Connections of the human orbitofrontal cortex and inferior frontal gyrus
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Heather Hsu, Chih-Chin, Rolls, Edmund T., Huang, Chu-Chung, Chong, Shin Tai, Zac Lo, Chun-Yi, Feng, Jianfeng and Lin, Ching-Po (2020) Connections of the human orbitofrontal cortex and inferior frontal gyrus. Cerebral Cortex, 30 (11). pp. 5830-5843. doi:10.1093/cercor/bhaa160
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WRAP-connections-human-orbitofrontal-cortex-inferior-frontal-gyrus-Rolls-2020.pdf - Accepted Version - Requires a PDF viewer. Download (2608Kb) | Preview |
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Official URL: http://dx.doi.org/10.1093/cercor/bhaa160
Abstract
The direct connections of the orbitofrontal cortex (OFC) were traced with diffusion tractography imaging and statistical analysis in 50 humans, to help understand better its roles in emotion and its disorders. The medial OFC and ventromedial prefrontal cortex have direct connections with the pregenual and subgenual parts of the anterior cingulate cortex; all of which are reward-related areas. The lateral OFC (OFClat) and its closely connected right inferior frontal gyrus (rIFG) have direct connections with the supracallosal anterior cingulate cortex; all of which are punishment or nonreward-related areas. The OFClat and rIFG also have direct connections with the right supramarginal gyrus and inferior parietal cortex, and with some premotor cortical areas, which may provide outputs for the OFClat and rIFG. Another key finding is that the ventromedial prefrontal cortex shares with the medial OFC especially strong outputs to the nucleus accumbens and olfactory tubercle, which comprise the ventral striatum, whereas the other regions have more widespread outputs to the striatum. Direct connections of the OFC and IFG were with especially the temporal pole part of the temporal lobe. The left IFG, which includes Broca’s area, has direct connections with the left angular and supramarginal gyri.
| Item Type: | Journal Article | |||||||||||||||||||||||||||
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| Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Computer Science | |||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Prefrontal cortex, Prefrontal cortex -- Imaging, Diagnostic imaging -- Statistical methods, Emotions and cognition | |||||||||||||||||||||||||||
| Journal or Publication Title: | Cerebral Cortex | |||||||||||||||||||||||||||
| Publisher: | Oxford University Press | |||||||||||||||||||||||||||
| ISSN: | 1047-3211 | |||||||||||||||||||||||||||
| Official Date: | November 2020 | |||||||||||||||||||||||||||
| Dates: |
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| Volume: | 30 | |||||||||||||||||||||||||||
| Number: | 11 | |||||||||||||||||||||||||||
| Page Range: | pp. 5830-5843 | |||||||||||||||||||||||||||
| DOI: | 10.1093/cercor/bhaa160 | |||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||
| Publisher Statement: | This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Chih-Chin Heather Hsu, Edmund T Rolls, Chu-Chung Huang, Shin Tai Chong, Chun-Yi Zac Lo, Jianfeng Feng, Ching-Po Lin, Connections of the Human Orbitofrontal Cortex and Inferior Frontal Gyrus, Cerebral Cortex, is available online at: https://doi.org/10.1093/cercor/bhaa160 | |||||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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