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Connections of the human orbitofrontal cortex and inferior frontal gyrus

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Heather Hsu, Chih-Chin, Rolls, Edmund T., Huang, Chu-Chung, Chong, Shin Tai, Zac Lo, Chun-Yi, Feng, Jianfeng and Lin, Ching-Po (2020) Connections of the human orbitofrontal cortex and inferior frontal gyrus. Cerebral Cortex, 30 (11). pp. 5830-5843. doi:10.1093/cercor/bhaa160

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Official URL: http://dx.doi.org/10.1093/cercor/bhaa160

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Abstract

The direct connections of the orbitofrontal cortex (OFC) were traced with diffusion tractography imaging and statistical analysis in 50 humans, to help understand better its roles in emotion and its disorders. The medial OFC and ventromedial prefrontal cortex have direct connections with the pregenual and subgenual parts of the anterior cingulate cortex; all of which are reward-related areas. The lateral OFC (OFClat) and its closely connected right inferior frontal gyrus (rIFG) have direct connections with the supracallosal anterior cingulate cortex; all of which are punishment or nonreward-related areas. The OFClat and rIFG also have direct connections with the right supramarginal gyrus and inferior parietal cortex, and with some premotor cortical areas, which may provide outputs for the OFClat and rIFG. Another key finding is that the ventromedial prefrontal cortex shares with the medial OFC especially strong outputs to the nucleus accumbens and olfactory tubercle, which comprise the ventral striatum, whereas the other regions have more widespread outputs to the striatum. Direct connections of the OFC and IFG were with especially the temporal pole part of the temporal lobe. The left IFG, which includes Broca’s area, has direct connections with the left angular and supramarginal gyri.

Item Type: Journal Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH): Prefrontal cortex, Prefrontal cortex -- Imaging, Diagnostic imaging -- Statistical methods, Emotions and cognition
Journal or Publication Title: Cerebral Cortex
Publisher: Oxford University Press
ISSN: 1047-3211
Official Date: November 2020
Dates:
DateEvent
November 2020Published
17 June 2020Available
20 May 2020Accepted
Volume: 30
Number: 11
Page Range: pp. 5830-5843
DOI: 10.1093/cercor/bhaa160
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Chih-Chin Heather Hsu, Edmund T Rolls, Chu-Chung Huang, Shin Tai Chong, Chun-Yi Zac Lo, Jianfeng Feng, Ching-Po Lin, Connections of the Human Orbitofrontal Cortex and Inferior Frontal Gyrus, Cerebral Cortex, is available online at: https://doi.org/10.1093/cercor/bhaa160
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MOST 109-2634-F-010-001Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
MOST 108-2321B-010-013-MY2Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
MOST 108-2321-B-010-010-MY2Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
MOST 108-2420-H-010001-Ministry of Science and Technology, TaiwanUNSPECIFIED
NHRI-EX108-10611EINational Health Research Instituteshttp://dx.doi.org/10.13039/501100004737
2018YFC0910503National Basic Research Program of China (973 Program)http://dx.doi.org/10.13039/501100012166
81801774[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
18ZR1403700Natural Science Foundation of Shanghaihttp://dx.doi.org/10.13039/100007219

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