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Sensation-seeking is related to functional connectivities of the medial orbitofrontal cortex with the anterior cingulate cortex
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Wan, Zhuo, Rolls, Edmund T., Cheng, Wei and Feng, Jianfeng (2020) Sensation-seeking is related to functional connectivities of the medial orbitofrontal cortex with the anterior cingulate cortex. NeuroImage, 215 . 116845. doi:10.1016/j.neuroimage.2020.116845
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WRAP-sensation-seeking-related-functional-connectivities-medial-orbitofrontal-cortex-anterior-cingulate-cortex-Rolls-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1228Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.neuroimage.2020.116845
Abstract
Sensation-seeking is a multifaceted personality trait with components that include experience-seeking, thrill and adventure seeking, disinhibition, and susceptibility to boredom, and is an aspect of impulsiveness. We analysed brain regions involved in sensation-seeking in a large-scale study with 414 participants and showed that the sensation-seeking score could be optimally predicted from the functional connectivity with typically (in different participants) 18 links between brain areas (measured in the resting state with fMRI) with correlation r = 0.34 (p = 7.3 × 10−13) between the predicted and actual sensation-seeking score across all participants. Interestingly, 8 of the 11 links that were common for all participants were between the medial orbitofrontal cortex and the anterior cingulate cortex and yielded a prediction accuracy r = 0.30 (p = 4.8 × 10−10). We propose that this important aspect of personality, sensation-seeking, reflects a strong effect of reward (in which the medial orbitofrontal cortex is implicated) on promoting actions to obtain rewards (in which the anterior cingulate cortex is implicated). Risk-taking was found to have a moderate correlation with sensation-seeking (r = 0.49, p = 3.9 × 10−26), and three of these functional connectivities were significantly correlated (p < 0.05) with the overall risk-taking score. This discovery helps to show how the medial orbitofrontal and anterior cingulate cortices influence behaviour and personality, and indicate that sensation-seeking can involve in part the medial orbitofrontal cortex reward system, which can thereby become associated with risk-taking and a type of impulsiveness.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science > Computer Science | ||||||||
| Library of Congress Subject Headings (LCSH): | Prefrontal cortex , Frontal lobes , Computational neuroscience, Brain -- Localization of functions | ||||||||
| Journal or Publication Title: | NeuroImage | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 1053-8119 | ||||||||
| Official Date: | 15 July 2020 | ||||||||
| Dates: |
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| Volume: | 215 | ||||||||
| Article Number: | 116845 | ||||||||
| DOI: | 10.1016/j.neuroimage.2020.116845 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
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