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Sensation-seeking is related to functional connectivities of the medial orbitofrontal cortex with the anterior cingulate cortex

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Wan, Zhuo, Rolls, Edmund T., Cheng, Wei and Feng, Jianfeng (2020) Sensation-seeking is related to functional connectivities of the medial orbitofrontal cortex with the anterior cingulate cortex. NeuroImage, 215 . 116845. doi:10.1016/j.neuroimage.2020.116845

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Official URL: http://dx.doi.org/10.1016/j.neuroimage.2020.116845

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Abstract

Sensation-seeking is a multifaceted personality trait with components that include experience-seeking, thrill and adventure seeking, disinhibition, and susceptibility to boredom, and is an aspect of impulsiveness. We analysed brain regions involved in sensation-seeking in a large-scale study with 414 participants and showed that the sensation-seeking score could be optimally predicted from the functional connectivity with typically (in different participants) 18 links between brain areas (measured in the resting state with fMRI) with correlation r ​= ​0.34 (p ​= ​7.3 ​× ​10−13) between the predicted and actual sensation-seeking score across all participants. Interestingly, 8 of the 11 links that were common for all participants were between the medial orbitofrontal cortex and the anterior cingulate cortex and yielded a prediction accuracy r ​= ​0.30 (p ​= ​4.8 ​× ​10−10). We propose that this important aspect of personality, sensation-seeking, reflects a strong effect of reward (in which the medial orbitofrontal cortex is implicated) on promoting actions to obtain rewards (in which the anterior cingulate cortex is implicated). Risk-taking was found to have a moderate correlation with sensation-seeking (r ​= ​0.49, p ​= ​3.9 ​× ​10−26), and three of these functional connectivities were significantly correlated (p ​< ​0.05) with the overall risk-taking score. This discovery helps to show how the medial orbitofrontal and anterior cingulate cortices influence behaviour and personality, and indicate that sensation-seeking can involve in part the medial orbitofrontal cortex reward system, which can thereby become associated with risk-taking and a type of impulsiveness.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH): Prefrontal cortex , Frontal lobes , Computational neuroscience, Brain -- Localization of functions
Journal or Publication Title: NeuroImage
Publisher: Elsevier
ISSN: 1053-8119
Official Date: 15 July 2020
Dates:
DateEvent
15 July 2020Published
11 April 2020Available
6 April 2020Accepted
Date of first compliant deposit: 26 June 2020
Volume: 215
Article Number: 116845
DOI: 10.1016/j.neuroimage.2020.116845
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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