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Sleep duration, brain structure, and psychiatric and cognitive problems in children
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Cheng, Wei, Rolls, Edmund T., Gong, Weikang, Du, Jingnan, Zhang, Jie, Zhang, Xiao-Yong, Li, Fei and Feng, Jianfeng (2021) Sleep duration, brain structure, and psychiatric and cognitive problems in children. Molecular Psychiatry, 26 . pp. 3992-4003. doi:10.1038/s41380-020-0663-2 ISSN 1359-4184.
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Official URL: http://dx.doi.org/10.1038/s41380-020-0663-2
Abstract
Low sleep duration in adults is correlated with psychiatric and cognitive problems. We performed for the first time a large-scale analysis of sleep duration in children, and how this relates to psychiatric problems including depression, to cognition, and to brain structure. Structural MRI was analyzed in relation to sleep duration, and psychiatric and cognitive measures in 11,067 9–11-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study, using a linear mixed model, mediation analysis, and structural equation methods in a longitudinal analysis. Dimensional psychopathology (including depression, anxiety, impulsive behavior) in the children was negatively correlated with sleep duration. Dimensional psychopathology in the parents was also correlated with short sleep duration in their children. The brain areas in which higher volume was correlated with longer sleep duration included the orbitofrontal cortex, prefrontal and temporal cortex, precuneus, and supramarginal gyrus. Longitudinal data analysis showed that the psychiatric problems, especially the depressive problems, were significantly associated with short sleep duration 1 year later. Further, mediation analysis showed that depressive problems significantly mediate the effect of these brain regions on sleep. Higher cognitive scores were associated with higher volume of the prefrontal cortex, temporal cortex, and medial orbitofrontal cortex. Public health implications are that psychopathology in the parents should be considered in relation to sleep problems in children. Moreover, we show that brain structure is associated with sleep problems in children, and that this is related to whether or not the child has depressive problems.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Sleep , Children -- Sleep, Sleep disorders in children , Brain -- Growth, Brain -- Anatomy, Cognition, Sleep -- Health aspects, Cognition disorders in children | |||||||||||||||||||||
Journal or Publication Title: | Molecular Psychiatry | |||||||||||||||||||||
Publisher: | Nature Publishing Group | |||||||||||||||||||||
ISSN: | 1359-4184 | |||||||||||||||||||||
Official Date: | August 2021 | |||||||||||||||||||||
Dates: |
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Volume: | 26 | |||||||||||||||||||||
Page Range: | pp. 3992-4003 | |||||||||||||||||||||
DOI: | 10.1038/s41380-020-0663-2 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
Date of first compliant deposit: | 26 June 2020 | |||||||||||||||||||||
Date of first compliant Open Access: | 3 August 2021 | |||||||||||||||||||||
Grant number: | Shanghai Municipal Scien | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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